食管鳞状细胞癌病理特征的多变量分析：肿瘤芽生是一个重要的独立预后因素。
Multivariate analysis of the pathologic features of esophageal squamous cell cancer: tumor budding is a significant independent prognostic factor.
作者信息
Koike Masahiko, Kodera Yasuhiro, Itoh Yuichi, Nakayama Goro, Fujiwara Michitaka, Hamajima Nobuyuki, Nakao Akimasa
机构信息
Department of Surgery II, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
出版信息
Ann Surg Oncol. 2008 Jul;15(7):1977-82. doi: 10.1245/s10434-008-9901-6. Epub 2008 Apr 12.
BACKGROUND
Tumor budding has been suggested to be a prognostic factor in various cancers but has never been studied in esophageal cancer.
METHODS
In this study, the microscopic finding of tumor budding in esophageal squamous cell carcinoma was correlated with outcome after esophagectomy. One hundred and thirty-six patients undergoing a curative esophagectomy were assigned to either a frequent (n = 82) or rare (n = 54) group according to the microscopically observed frequency of tumor budding in the tumor.
RESULTS
The 5-year survival rates after esophagectomy were 35.4% for the frequent group and 81.3% for the rare group. Multivariate analysis using the Cox proportional hazards model by a stepwise method identified this morphological variable as a significant independent prognostic factor.
CONCLUSIONS
Tumor budding in esophageal squamous cell carcinoma reflects the biological activity of the tumor and may be a useful prognostic indicator.
背景
肿瘤芽生已被认为是多种癌症的预后因素，但从未在食管癌中进行过研究。
方法
在本研究中，食管鳞状细胞癌肿瘤芽生的微观表现与食管切除术后的预后相关。136例行根治性食管切除术的患者根据肿瘤中显微镜下观察到的肿瘤芽生频率分为频繁组（n = 82）或罕见组（n = 54）。
结果
食管切除术后频繁组的5年生存率为35.4%，罕见组为81.3%。采用逐步法通过Cox比例风险模型进行多变量分析，确定这一形态学变量为显著的独立预后因素。
结论
食管鳞状细胞癌中的肿瘤芽生反映了肿瘤的生物学活性，可能是一个有用的预后指标。
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