Rathod Gunvanti B, Desai Killol N, Shrivastava Atul, Maru Alpeshkumar M
Pathology, AIl India Institute of Medical Sciences (AIIMS), Hyderabad, IND.
Pathology, Nootan Medical College & Research Centre, Visnagar, IND.
Cureus. 2022 Sep 26;14(9):e29637. doi: 10.7759/cureus.29637. eCollection 2022 Sep.
: Tumor blossoming may be a predictive indicator for a variety of cancers. At the invasive origin of the tumor, cells get detached from the original tumor mass. : Studying breast cancer tumor budding, as well as its link to other prognostic indicators, such as clinicopathological features and hormone receptor status, will be the focus of this study. : Over six years, 110 cases of invasive breast cancer were examined. Ten high-power fields were used to analyze H&E-stained slices for tumor sprouting. It was determined that the tumor buds were divided into low and high grades. Tumor budding and other prognostic factors were compared using the chi-square test. It was considered significant if the p-value was less than or equal to 0.05. : There were 110 cases of invasive ductal carcinoma, which accounts for more than half of the total cases (88.18%). A total of 144 tumors were present, of which 74 displayed strong budding and 36 displayed poor budding. A correlation between tumor budding and tumor size, lymph node metastasis, and tumor stage is statistically significant (P = 0.0099). : Tumor budding in breast cancer is an easily visible in microscopy, novel prognostic indicator. A new prognostic element may be added to the reporting process.
肿瘤芽生可能是多种癌症的预测指标。在肿瘤的侵袭起源处，细胞从原始肿瘤块上脱离。：研究乳腺癌肿瘤芽生及其与其他预后指标（如临床病理特征和激素受体状态）的联系，将是本研究的重点。：在六年多的时间里，对110例浸润性乳腺癌病例进行了检查。使用十个高倍视野分析苏木精-伊红染色切片中的肿瘤芽生情况。确定肿瘤芽分为低级别和高级别。使用卡方检验比较肿瘤芽生和其他预后因素。如果p值小于或等于0.05，则认为具有显著性。：有110例浸润性导管癌，占总病例数的一半以上（88.18%）。共有144个肿瘤，其中74个显示强烈芽生，36个显示芽生不良。肿瘤芽生与肿瘤大小、淋巴结转移和肿瘤分期之间的相关性具有统计学意义（P = 0.0099）。：乳腺癌中的肿瘤芽生在显微镜下很容易观察到，是一种新的预后指标。可以在报告过程中添加一个新的预后要素。
