Stouten Hans, Ott Heidi, Bouwman Carolien, Wardenbach Peter
Health Council of the Netherlands, The Hague, The Netherlands.
Am J Ind Med. 2008 Jun;51(6):407-18. doi: 10.1002/ajim.20579.
Although the Netherlands currently has its own procedure for evaluating chemical compounds and setting occupational exposure limits (OELs), most of these limits were originally adopted in the 1970s from threshold limit values (TLVs) set by the American Conference of Governmental Industrial Hygienists (ACGIH). However, beginning in the late 1980s, criticism about non-scientific considerations being used to set TLV's suggested that TLVs might not offer sufficient health protection to workers. This situation prompted the Dutch Ministry of Social Affairs and Employment to request that the Health Council of the Netherlands reassess the health protection of MAC values that were contained in the 1994 Dutch MAC list.
Criteria documents were prepared for 161 compounds. They were evaluated by a committee of the Health Council of the Netherlands consisting of international experts who reassessed the toxicological hazards of these substances and recommended, whenever possible, health-based OELs. The results of the reassessment by the Health Council were compared with the MAC values of the 1994 Dutch MAC list, ACGIH TLVs, and existing German OELs.
The toxicological database met the committee's criteria for a health-based OEL for only about 40% of the compounds.
Many older MAC values were either too high or not scientifically supported and therefore not health-based.
尽管荷兰目前有自己的程序来评估化学化合物并设定职业接触限值（OELs），但这些限值大多最初于20世纪70年代采用美国政府工业卫生学家会议（ACGIH）设定的阈限值（TLVs）。然而，从20世纪80年代末开始，有关在设定TLV时使用非科学考量因素的批评表明，TLV可能无法为工人提供足够的健康保护。这种情况促使荷兰社会事务和就业部要求荷兰卫生委员会重新评估1994年荷兰MAC清单中所含MAC值的健康保护情况。
为161种化合物编写了标准文件。由荷兰卫生委员会的一个委员会进行评估，该委员会由国际专家组成，他们重新评估了这些物质的毒理学危害，并尽可能建议基于健康的OELs。将卫生委员会重新评估的结果与1994年荷兰MAC清单的MAC值、ACGIH TLVs和现有的德国OELs进行了比较。
毒理学数据库仅约40%的化合物符合委员会基于健康的OEL标准。
许多较早的MAC值要么过高，要么缺乏科学依据，因此并非基于健康。
