Mamon L A
Tsitologiia. 2008;50(1):5-17.
Centrosomes are the major centre of microtubule nucleation and microtubule minus-ends concentration in animal cells. Microtubule plus-ends are directed to a nucleus and chromosomes or to a cell cortex. The crossing of signal transduction pathways and the network of interactions between signal molecules controlling cell cycle are revealed in centrosomes. The ability of centrosomes for reduplication suggests the existence of hypothetic template elements. It is attractive to suggest the essential role of specific centrosome-associated RNAs in biogenesis of centrosomes. Untranslated RNAs playing a structural role and mRNAs that are localized in centrosomes to regulate protein synthesis in close proximity to mitotic apparatus may be present among these RNAs. Centrosomes positioning plays the important role in determining of cell polarity. Centrosomes are critical for the formation and support of cilia and flagella having motility or sensory functions.
中心体是动物细胞中微管成核和微管负端聚集的主要中心。微管正端指向细胞核、染色体或细胞皮层。在中心体中揭示了信号转导途径的交叉以及控制细胞周期的信号分子之间的相互作用网络。中心体的复制能力表明存在假设的模板元件。提出特定的中心体相关RNA在中心体生物发生中起重要作用很有吸引力。这些RNA中可能存在起结构作用的非翻译RNA以及定位于中心体以调节靠近有丝分裂装置处蛋白质合成的mRNA。中心体定位在确定细胞极性中起重要作用。中心体对于具有运动或感觉功能的纤毛和鞭毛的形成和维持至关重要。
