Doxsey S
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA.
Nat Rev Mol Cell Biol. 2001 Sep;2(9):688-98. doi: 10.1038/35089575.
Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.
在过去的100年里，中心体的地位已从一个位于微管焦点处的神秘细胞器，上升为细胞周期进程和细胞调控中的关键角色。越来越多的证据表明，中心体对于纺锤体组装可能并非必不可少，而最近的数据表明，它们对于启动S期和完成胞质分裂可能很重要。已经鉴定出调节中心体复制的分子，并且不断增加的一系列有趣的中心体锚定活性（其功能尚未确定）有望带来持续的发现。
