Makrushin A V
Zh Obshch Biol. 2008 Jan-Feb;69(1):19-24.
A hypothesis explaning the nature of ageing and carcinogenesis is proposed. The hypothesis is based on the notion of a unitary organism as a module of a colony that has lost the ability to reproduce asexually. The evolutionary forerunner of the old age involution was the asexual iteroparity of colony modules, and the evolutionary forerunner of carcinogenesis was the semelparity of such colonies; the evolutionary forerunner or tumour regression was the switch of the colony module from semelparity to iteroparity. The donor-acceptor relations of a colony module emerge in unitary organisms in the course of ageing and carcinogenesis. The mechanisms of ageing and carcinogenesis originated at the stages of Metazoa evolution when the organisms had not yet acquired the nervous and the endocrine systems.
提出了一种解释衰老和致癌作用本质的假说。该假说基于这样一种观念，即单一生物体是一个已失去无性繁殖能力的群体的模块。老年退化的进化先驱是群体模块的无性反复生殖，而致癌作用的进化先驱是此类群体的单次生殖；肿瘤消退的进化先驱是群体模块从单次生殖转变为反复生殖。群体模块的供体 - 受体关系在单一生物体衰老和致癌过程中出现。衰老和致癌作用的机制起源于后生动物进化阶段，那时生物体尚未获得神经和内分泌系统。
