Albini E, Benedetti L, Caruso A, Marchetti S, Nan E, Zoni S, Lucchini R
Cattedra di Medicina del Lavoro, Università degli Sudi di Brescia.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):272-4.
Our Institute has been following for 20 years a group of workers of a ferroalloy industry in order to evaluate neurobehavioral effects due to manganese exposure. Five years after the last study we have planned another one, to evaluate differences in neuromotor e cognitive functions between exposed and controls and to perform a longitudinal evaluation of the results. Environmental and biological sampling were collected, liver and kidney functionality, haemochrome, iron metabolism and sieric prolactine were evaluated. Several tests were administered: postural evaluation, tremor, four tests of the SPES battery, Pursuing Aiming, five tests of the Luria Nebraska Motor Battery, Raven Progressive Matrices, Trail Making Test, Mood Scale, Brief Symptoms Inventory, neuropsychological symptoms questionnaire. Personal habits and working, living and clinical histories were collected. We evaluated 43 exposed workers and 40 controls. Exposure indicators resulted all significantly higher in exposed workers. Neuropsychological examination showed differences in Raven Progressive Matrices and Pursuit Aiming, higher tremor values and differences in postural evaluation between exposed and controls.
我们研究所对一群铁合金行业的工人进行了20年的跟踪研究，以评估锰暴露对神经行为的影响。在上次研究五年后，我们计划开展另一项研究，以评估暴露组与对照组在神经运动和认知功能方面的差异，并对结果进行纵向评估。我们采集了环境和生物样本，评估了肝脏和肾脏功能、血红蛋白、铁代谢和血清催乳素。进行了多项测试：姿势评估、震颤测试、SPES测试组合中的四项测试、追踪瞄准测试、鲁利亚-内布拉斯加运动测试组合中的五项测试、瑞文渐进性矩阵测试、连线测验、情绪量表、简明症状量表、神经心理症状问卷。收集了个人习惯以及工作、生活和临床病史。我们评估了43名暴露工人和40名对照组人员。结果显示，暴露工人的暴露指标均显著更高。神经心理学检查表明，暴露组与对照组在瑞文渐进性矩阵测试和追踪瞄准测试中存在差异，震颤值更高，姿势评估也存在差异。
