Urbano M L, Di Lorenzo L, Russo A, Corfiati M, Gagliardi T, Silvestroni A, Lovreglio P, Tempesta M, Cassano F, Soleo L
Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro, Università di Bari, Italy.
G Ital Med Lav Ergon. 2005 Jan-Mar;27 Suppl 1:62-7.
The effects of low-dose lead occupational exposure on neurobehavioral functions are still not well defined by international literature. The objective of this study is to assess by psychometric testing the presence of possible neuropsychological impairment in a group of male Italian workers with low blood lead levels in comparison to an adequate non exposed worker group. Given informed consent to take part to the study, all workers were interviewed about their working and clinical history and underwent determination of blood lead levels (PbB). An internationally validated computerized battery of psychometric tests and a standardized paper-and-pencil version of mood self-rating scale and WAIS-R Vocabulary subtest were also administered to the workers. Exposed workers had a geometric mean of PbB significantly higher than non exposed workers, but rather low (16.4 +/- 1.7 microg/dl). The results of psychometric tests were not significantly different between the two worker groups, even after adjusting for the main confounding factors. In workers exposed to low lead doses no neurobehavioral abnormalities were demonstrated by the administered psychometric test battery.
低剂量铅职业暴露对神经行为功能的影响在国际文献中仍未得到明确界定。本研究的目的是通过心理测量测试,评估一组血铅水平较低的意大利男性工人与一组适当的未暴露工人相比,是否存在可能的神经心理损伤。在获得参与研究的知情同意后,对所有工人进行了工作和临床病史访谈,并测定了血铅水平(PbB)。还对工人们进行了一组经过国际验证的计算机化心理测量测试,以及一份标准化的纸笔版情绪自评量表和韦氏成人智力量表修订版(WAIS-R)词汇子测试。暴露组工人的血铅几何平均值显著高于未暴露组工人,但相当低(16.4±1.7微克/分升)。即使在对主要混杂因素进行调整后,两个工人群体的心理测量测试结果也没有显著差异。在低铅剂量暴露的工人中,所采用的心理测量测试组合未显示出神经行为异常。