Squitti R, Gorgone G, Binetti G, Ghidoni R, Pasqualetti P, Draicchio F, Albini E, Benedetti L, Lucchini R, Rossini P M
Dipartimento di Neuroscienze, AFaR - FBF Ospedale Fatebenefratelli, Italia.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):294-6.
Parkinson's disease (PD) is characterized by a progressive degeneration of the nigrostriatal dopaminergic pathway resulting in movement disorders. PD is a complex disease, in which and environmental factors, as exposure to toxins or metals coul be involved.
To assess if serum metals (Cu, Fe, Zn), biological variables of their metabolism, total peroxides and antioxidants were abnormal in PD, in relation to environmental exposure.
We compared levels of serum copper, iron, zinc, ceruloplasmin and transferrin, peroxides, antioxidants (TRAP) in 65 PD patients coming from an Industrial zone highly exposed to metal pollution (Valcamonica) with measures from 28 PD patients from no metal pollution areas of the province of Brescia and 52 healthy controls coming from Valcamonica and 24 from the province of Brescia.
PD patients had higher serum concentration of zinc than controls. Only in PD patients coming from Valcamonica levels of Cu were higher than in subjects coming from the province of Brescia. Moreover, In patients with PD levels of sieric Cu significantly correlated with score of the Unified Parkinson's Disease Rating Scale (UDPRS).
Zinc seems to be higher in PD independently from the exposition to metal pollution. Perturbation of copper metabolism in PD seems to be related to exposition to environmental toxins or metal pollution and coul be involved in the progression of the disease itself.
帕金森病（PD）的特征是黑质纹状体多巴胺能通路进行性退化，导致运动障碍。PD是一种复杂疾病，可能涉及环境因素，如接触毒素或金属。
评估PD患者血清金属（铜、铁、锌）、其代谢的生物学变量、总过氧化物和抗氧化剂是否与环境暴露相关而异常。
我们比较了来自金属污染高度暴露工业区（瓦尔卡莫尼卡）的65例PD患者的血清铜、铁、锌、铜蓝蛋白和转铁蛋白、过氧化物、抗氧化剂（TRAP）水平，以及来自布雷西亚省无金属污染地区的28例PD患者和来自瓦尔卡莫尼卡的52例健康对照者及来自布雷西亚省的24例健康对照者的测量值。
PD患者血清锌浓度高于对照组。仅来自瓦尔卡莫尼卡的PD患者铜水平高于来自布雷西亚省的受试者。此外，PD患者血清铜水平与统一帕金森病评定量表（UPDRS）评分显著相关。
PD患者锌水平似乎较高，与金属污染暴露无关。PD患者铜代谢紊乱似乎与环境毒素或金属污染暴露有关，可能参与疾病本身的进展。
