D'Ovidio M C, Martini A, Signorini S
ISPESL, Dipartimento di Medicina del Lavoro, Monte Porzio Catone, Roma.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):489-91.
Animal laboratory workers are exposed at the Laboratory Animal Allergy (LAA). About 10% of them develop asthma. Currently, by the use of innovative methodologies, numerous allergens from the laboratory animals have been sequenced and analyzed. Between them, the allergens by rats and mouse, the experimental models more utilized. Proteomic approach or protein microarray permit the study of several allergens, belonging to the proteins known as lipocalins, and of immunological response in susceptible individuals. Moreover, availability of on-line data banks permit a knowledge more and more detailed and up-to-date regarding the allergens of the interest. Between the advantage of the proteomic there is the use of small amount of biological fluids, as the serum, in association with the possibility to studied a great number of allergens on a single support. The study of LAA by the use of proteomic will permit to identify the animal allergens more accurately, providing also a valid tool at the methodologies traditionally used, and for the planning of the preventive and protective measures.
动物实验室工作人员会接触到实验动物过敏（LAA）。其中约10%的人会患上哮喘。目前，通过使用创新方法，已对众多实验动物过敏原进行了测序和分析。其中，大鼠和小鼠的过敏原是使用较多的实验模型。蛋白质组学方法或蛋白质微阵列可用于研究几种属于脂质运载蛋白的过敏原，以及易感个体的免疫反应。此外，在线数据库的可用性使人们对相关过敏原的了解越来越详细和最新。蛋白质组学的优势之一是使用少量生物体液（如血清），同时有可能在单一载体上研究大量过敏原。通过蛋白质组学研究LAA将有助于更准确地识别动物过敏原，为传统使用的方法以及预防和保护措施的规划提供有效的工具。
