Valentino M, Rapisarda V, Scorcelletti M, Caldaroni M, Mariani F
Dipartimento di Patologia Molecolare e Terapie Innovative, Clinica di Medicina del Lavoro, Università Politecnica delle Marche, Ancona, Italia.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):555-6.
The effectiveness of t,t-muconic acid (t,t-MA) has been investigated as indicator of benzene exposure in workers of an oil refinery. 196 blue collar workers that operate in the field and 25 white collar workers who work in administration have been studied. Workers had not chronic diseases; all workers resulted fit to work. The environmental monitoring, effected with personal and fixed samplers (141 samplings), has shown that benzene air levels were lower than 170 mcg/m3. Biological monitoring was performed with measurements of blood benzene, urinary t,t-MA and urinary phenols. Each worker has been questioned regarding smoking habit, consumption of food containing sorbic acid and non-occupational exposure to benzene. Values of biological index were: t,t-MA 88 +/- 94.1 mcg/g cr, phenols 17.7 +/- 2.9 mg/g cr, blood benzene 25.4 +/- 4.3 ng/l. No significant differences were found between blue and white collars respect t,t-MA, phenols, blood benzene, non-occupational exposure to benzene, smoking habit, consumption of food containing sorbic acid. A meaningful correlation was found between the t,t-MA and the ingestion of the number of foods containing sorbic acid (r = 0.87). The results confirm that the t,t-MA seems incapable to distinguish occupationally exposed workers, at low levels of benzene exposure, from unexposed.
已对炼油厂工人中反,反-粘康酸（t,t-MA）作为苯暴露指标的有效性进行了研究。研究了196名在现场作业的蓝领工人和25名从事行政管理工作的白领工人。这些工人没有慢性病；所有工人都适合工作。使用个人和固定采样器进行的环境监测（共141次采样）表明，空气中苯的含量低于170微克/立方米。通过测量血苯、尿中反,反-粘康酸和尿酚进行生物监测。每位工人都被询问了吸烟习惯、含山梨酸食品的摄入量以及非职业性苯暴露情况。生物指标的值为：反,反-粘康酸88±94.1微克/克肌酐，酚类17.7±2.9毫克/克肌酐，血苯25.4±4.3纳克/升。在蓝领和白领之间，就反,反-粘康酸、酚类、血苯、非职业性苯暴露、吸烟习惯、含山梨酸食品的摄入量而言，未发现显著差异。在反,反-粘康酸与含山梨酸食品的摄入数量之间发现了有意义的相关性（r = 0.87）。结果证实，在低水平苯暴露情况下，反,反-粘康酸似乎无法区分职业暴露工人和未暴露工人。
