Fustinoni Silvia, Buratti Marina, Campo Laura, Colombi Antonio, Consonni Dario, Pesatori Angela C, Bonzini Matteo, Farmer Peter, Garte Seymour, Valerio Federico, Merlo Domenico F, Bertazzi Pier A
Department of Occupational and Environmental Health, University of Milan and Fondazione Policlinico, Mangiagalli e Regina Elena, Via S. Barnaba, 8, 20122-Milan, Italy.
Chem Biol Interact. 2005 May 30;153-154:253-6. doi: 10.1016/j.cbi.2005.03.031. Epub 2005 Apr 18.
This research compared the capability of urinary trans,trans-muconic acid (t,t-MA), S-phenylmercapturic acid (S-PMA) and benzene excreted in urine (U-benzene) to monitor low benzene exposure and evaluated the influence of smoking habit on these indices. Gasoline attendants, urban policemen, bus drivers and two groups of referents working in two large Italian cities (415 people) were studied. Median benzene exposure was 61, 22, 21, 9 and 6 microg/m3, respectively, with higher levels in workers than in referents. U-benzene, but not t,t-MA and S-PMA, showed an exposure-related increase. All the biomarkers were strongly influenced by cigarette smoking, with values up to five-fold higher in smokers compared to non-smokers. In conclusion, in the range of investigated benzene exposure (<478 microg/m3 or <0.15 ppm), the smoking habit may be regarded as a major source of benzene intake; among the study indices, U-benzene is the marker of choice for the biological monitoring of occupational and environmental exposure.
本研究比较了尿中反，反-粘康酸（t,t-MA）、S-苯基巯基尿酸（S-PMA）和尿中苯排泄量（U-苯）监测低剂量苯暴露的能力，并评估了吸烟习惯对这些指标的影响。对意大利两个大城市的汽油加油工、城市警察、公交车司机以及两组对照人员（共415人）进行了研究。苯暴露中位数分别为61、22、21、9和6μg/m³，工人的暴露水平高于对照人员。U-苯呈现出与暴露相关的增加，而t,t-MA和S-PMA则不然。所有生物标志物都受到吸烟的强烈影响，吸烟者的值比不吸烟者高至五倍。总之，在所研究的苯暴露范围内（<478μg/m³或<0.15ppm），吸烟习惯可能被视为苯摄入的主要来源；在研究指标中，U-苯是职业和环境暴露生物监测的首选标志物。
