Anderson N E, Barber P A
Neurology Department, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand.
J Clin Neurosci. 2008 Sep;15(9):961-71. doi: 10.1016/j.jocn.2007.12.003. Epub 2008 Apr 14.
The clinical features of limbic encephalitis are diverse and early diagnosis of the disorder is frequently difficult. Four patients with limbic encephalitis are described. An antineuronal antibody was identified in three of these patients. Antibodies directed against voltage-gated potassium channels, the N-methyl-D-aspartate receptor and an unidentified neuropil antigen were each found in one patient. The fourth patient had multifocal paraneoplastic encephalitis associated with small cell lung cancer. The clinical and imaging findings associated with these antibodies and the other antineuronal antibodies described in patients with limbic encephalitis are reviewed. An approach to the diagnosis and management of limbic encephalitis is presented.
边缘叶脑炎的临床特征多样，该疾病的早期诊断常常困难。本文描述了4例边缘叶脑炎患者。其中3例患者检测到抗神经元抗体。分别在1例患者中发现了针对电压门控钾通道、N-甲基-D-天冬氨酸受体和一种未明确的神经毡抗原的抗体。第4例患者患有与小细胞肺癌相关的多灶性副肿瘤性脑炎。本文回顾了与这些抗体以及边缘叶脑炎患者中描述的其他抗神经元抗体相关的临床和影像学表现。并提出了边缘叶脑炎的诊断和管理方法。
