作为药物靶点的离子通道：下一个G蛋白偶联受体 - Suppr

Suppr

超能文献

Ion channels as drug targets: the next GPCRs.

作者信息

Kaczorowski Gregory J, McManus Owen B, Priest Birgit T, Garcia Maria L

机构信息

Department of Ion Channels, Merck Research Laboratories, Rahway, NJ 07065, USA.

出版信息

J Gen Physiol. 2008 May;131(5):399-405. doi: 10.1085/jgp.200709946. Epub 2008 Apr 14.

DOI:10.1085/jgp.200709946

PMID:18411331

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2346569/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8300/2346569/f01f14c64fa4/jgp1310399f01.jpg

相似文献

Ion channels as drug targets: the next GPCRs.作为药物靶点的离子通道：下一个G蛋白偶联受体

J Gen Physiol. 2008 May;131(5):399-405. doi: 10.1085/jgp.200709946. Epub 2008 Apr 14.

Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential.通过电刺激和膜电位荧光检测对电压门控钠通道阻滞剂进行表征。

Nat Biotechnol. 2006 Apr;24(4):439-46. doi: 10.1038/nbt1194. Epub 2006 Mar 19.

Effects of i.v. anaesthetics on human brain sodium channels.静脉麻醉药对人脑海马体钠通道的影响。

Br J Anaesth. 1993 Jul;71(1):15-24. doi: 10.1093/bja/71.1.15.

Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.心脏钠通道季铵盐利多卡因阻滞的动力学效应：门控电流研究

J Gen Physiol. 1994 Jan;103(1):19-43. doi: 10.1085/jgp.103.1.19.

Intracellular sodium overload: a system biology problem with implications for drug target identification.

J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S149-S150. doi: 10.1111/j.1540-8167.2006.00403.x.

Lidocaine alters activation gating of cardiac Na channels.利多卡因改变心脏钠通道的激活门控。

Pflugers Arch. 2000 Apr;439(6):814-21. doi: 10.1007/s004249900217.

Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.通过原毒素II捕获结构域II电压感受器来抑制钠通道门控。

Mol Pharmacol. 2008 Mar;73(3):1020-8. doi: 10.1124/mol.107.041046. Epub 2007 Dec 21.

Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.心脏钠通道的电压依赖性开放态失活：使用海葵毒素A的门控电流研究

J Gen Physiol. 1995 Oct;106(4):617-40. doi: 10.1085/jgp.106.4.617.

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.神经毒素对电压门控钠通道作用的分子机制

Biochimie. 2000 Sep-Oct;82(9-10):883-92. doi: 10.1016/s0300-9084(00)01174-3.

Four-mode gating model of fast inactivation of sodium channel Nav1.2a.钠通道Nav1.2a快速失活的四模式门控模型。

Pflugers Arch. 2008 Oct;457(1):103-19. doi: 10.1007/s00424-008-0500-y. Epub 2008 Apr 19.

引用本文的文献

Mechanism of Tethered Agonist Binding to an Adhesion G-Protein-Coupled Receptor.束缚激动剂与粘附性G蛋白偶联受体结合的机制。

bioRxiv. 2025 Aug 4:2025.08.04.668378. doi: 10.1101/2025.08.04.668378.

Modulating ion channels with nanobodies.利用纳米抗体调节离子通道

Synth Syst Biotechnol. 2025 Feb 18;10(2):593-599. doi: 10.1016/j.synbio.2025.02.005. eCollection 2025 Jun.

A synthetic method to assay polycystin channel biophysics.一种检测多囊蛋白通道生物物理学的合成方法。

Elife. 2024 Oct 28;13:RP98534. doi: 10.7554/eLife.98534.

Editorial: Targeting ion channels for drug discovery: emerging challenges for high throughput screening technologies.社论：以离子通道为药物研发靶点：高通量筛选技术面临的新挑战

Front Mol Neurosci. 2024 May 31;17:1414816. doi: 10.3389/fnmol.2024.1414816. eCollection 2024.

Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies.通过二价纳米抗体靶向募集NEDD4-2抑制离子通道

bioRxiv. 2024 May 31:2024.05.28.596281. doi: 10.1101/2024.05.28.596281.

A synthetic method to assay polycystin channel biophysics.一种用于检测多囊蛋白通道生物物理学的合成方法。

bioRxiv. 2024 Aug 10:2024.05.06.592666. doi: 10.1101/2024.05.06.592666.

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.靶向瞬时受体电位通道：结构、配体结合及分子机制的最新进展

Front Mol Neurosci. 2024 Jan 11;16:1334370. doi: 10.3389/fnmol.2023.1334370. eCollection 2023.

Evaluation of Cell-Free Synthesized Human Channel Proteins for In Vitro Channel Research.用于体外通道研究的无细胞合成人通道蛋白的评估

Membranes (Basel). 2022 Dec 30;13(1):48. doi: 10.3390/membranes13010048.

Computational design of peptides to target Na1.7 channel with high potency and selectivity for the treatment of pain.针对 Na1.7 通道进行高活性和高选择性的肽类药物设计，用于疼痛治疗。

Elife. 2022 Dec 28;11:e81727. doi: 10.7554/eLife.81727.

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening.奈必洛尔作为一种有效的瞬时受体电位阳离子通道亚家族M成员8（TRPM8）通道阻滞剂：一种通过自动膜片钳和基于配体的虚拟筛选进行药物筛选的方法。

Membranes (Basel). 2022 Sep 28;12(10):954. doi: 10.3390/membranes12100954.

本文引用的文献

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.一类新型电压门控钠通道Nav1.7强效抑制剂的特性研究

Biochemistry. 2007 Dec 18;46(50):14693-703. doi: 10.1021/bi7018207. Epub 2007 Nov 21.

From genes to pain: Na v 1.7 and human pain disorders.从基因到疼痛：钠通道蛋白1.7与人类疼痛障碍

Trends Neurosci. 2007 Nov;30(11):555-63. doi: 10.1016/j.tins.2007.08.004. Epub 2007 Oct 22.

Automated electrophysiology in drug discovery.药物研发中的自动化电生理学

Curr Pharm Des. 2007;13(23):2325-37. doi: 10.2174/138161207781368701.

Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.新型苯并氮杂䓬酮类电压门控钠通道1.7（Na(v)1.7）阻滞剂的发现：神经性疼痛的潜在治疗方法

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4630-4. doi: 10.1016/j.bmcl.2007.05.076. Epub 2007 May 27.

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.A-803467是一种强效且具有选择性的Nav1.8钠通道阻滞剂，可减轻大鼠的神经性疼痛和炎性疼痛。

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5. doi: 10.1073/pnas.0611364104. Epub 2007 May 2.

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.门控修饰毒素ProTx-II与NaV 1.5的分子相互作用：暗示存在与激活相关的新型毒素结合位点

J Biol Chem. 2007 Apr 27;282(17):12687-97. doi: 10.1074/jbc.M610462200. Epub 2007 Mar 5.

Blocking sodium channels to treat neuropathic pain.阻断钠通道治疗神经性疼痛。

Expert Opin Ther Targets. 2007 Mar;11(3):291-306. doi: 10.1517/14728222.11.3.291.

Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.钠通道阻滞可能有助于提高抗抑郁药的镇痛效果。

J Pain. 2007 Apr;8(4):315-24. doi: 10.1016/j.jpain.2006.10.001. Epub 2006 Dec 15.

Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.胰腺β细胞中延迟整流钾电流的阻滞剂可增强葡萄糖依赖性胰岛素分泌。

Diabetes. 2006 Apr;55(4):1034-42. doi: 10.2337/diabetes.55.04.06.db05-0788.

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.一种基于膜电位荧光共振能量转移的高容量检测Nav1.8通道的方法。

Assay Drug Dev Technol. 2006 Feb;4(1):37-48. doi: 10.1089/adt.2006.4.37.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验