Porritt G M, Reese C B
Department of Chemistry, King's College London, UK.
Nucleic Acids Symp Ser. 1989(21):55-6.
The conversion, in good yield, of 5'-O-(9-phenylxanthen-9-yl) thymidine (1) into the triethylammonium salt of its 3'-phosphonodithioate (2a) is described. The latter compound (2a) is converted into a dinucleoside phosphonothioate (4a), and thence into a corresponding dinucleoside phosphorodithioate (6a) and phosphorothioate (6;X = 0).
描述了5'-O-(9-苯基呫吨-9-基)胸苷(1)以良好产率转化为其3'-膦酰二硫代酸酯的三乙铵盐(2a)的过程。后一种化合物(2a)转化为二核苷膦酰硫代酸酯(4a)，并由此转化为相应的二核苷二硫代磷酸酯(6a)和硫代磷酸酯(6；X = O)。
