碱性磷酸酶在肾衰竭血管钙化中作为诱导剂的作用？
Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?
作者信息
Schoppet M, Shanahan C M
机构信息
Department of Internal Medicine and Cardiology, Philipps University, Marburg, Germany.
出版信息
Kidney Int. 2008 May;73(9):989-91. doi: 10.1038/ki.2008.104.
PMID:18414436
Abstract
Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.
摘要
血管钙化与心血管疾病发病率和死亡率的增加相关。最近已确定了多种钙化抑制剂，包括无机焦磷酸（PP(i)），它是羟基磷灰石晶体生长的一种重要物理化学抑制剂。在肾衰竭时，组织非特异性碱性磷酸酶（TNAP）对PP(i)的水解作用可能增强，从而促进血管矿化。
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