Yan Brian M, Van Dam Jacques
Division of Gastroenterology, University of Calgary, Calgary, Canada.
Can J Gastroenterol. 2008 Apr;22(4):405-10. doi: 10.1155/2008/104398.
Pancreatic cancer is the second most frequent gastrointestinal malignancy and carries a dismal prognosis. The current standard of care includes resection, if possible, as well as systemic chemoradiation therapy. Endoscopic ultrasound (EUS) is an established technique for the diagnosis and staging of pancreatic adenocarcinoma. Interventional EUS via fine needle injection (FNI) for the treatment of pancreatic cancer is a rapidly expanding field. The present article reviews the up-to-date developments in EUS FNI for intratumoural pancreatic cancer therapy, including antitumoural agents, immunotherapy, ablative techniques and new delivery systems. The therapeutic modalities discussed are currently under development and will hopefully reach clinical practice if benefit is demonstrated through clinical trials. EUS FNI may be an exciting new technique for the delivery of desperately needed novel therapies for pancreatic cancer.
胰腺癌是第二常见的胃肠道恶性肿瘤,预后不佳。目前的标准治疗方案包括在可能的情况下进行手术切除,以及全身放化疗。内镜超声(EUS)是诊断和分期胰腺腺癌的成熟技术。通过细针注射(FNI)进行的介入性EUS治疗胰腺癌是一个迅速发展的领域。本文综述了EUS FNI在胰腺肿瘤内治疗方面的最新进展,包括抗肿瘤药物、免疫治疗、消融技术和新的给药系统。所讨论的治疗方式目前仍在研发中,如果临床试验证明有获益,有望应用于临床实践。EUS FNI可能是一种令人兴奋的新技术,可为胰腺癌提供急需的新型治疗方法。