内镜超声引导下胰腺间质化疗：犬模型实验结果
Endoscopic ultrasound-guided interstitial chemotherapy in the pancreas: results in a canine model.
作者信息
Sun S, Wang S, Ge N, Lei T, Lu Q, Zhou Z, Yang A, Wang Z, Sun M
机构信息
Endoscopy Center, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China.
出版信息
Endoscopy. 2007 Jun;39(6):530-4. doi: 10.1055/s-2007-966353.
BACKGROUND AND STUDY AIM
Interstitial chemotherapy using surgically implanted, biodegradable polymers has been reported. Our aim in this study was to investigate the feasibility and safety of endoscopic ultrasound- (EUS-) guided interstitial chemotherapy of the pancreas in a canine model.
MATERIALS AND METHODS
A therapeutic 19-gauge needle with a large channel was inserted into the pancreas under EUS guidance. The polymers for sustained intratumoral release of 5-fluorouracil were implanted into the tissue by the needle. After 14 days of clinical observation, the animals were sacrificed and the tissue response to the local chemotherapy was examined.
RESULTS
All the polymers were implanted successfully and no implant migration occurred. Localized tissue fibrous necrosis was achieved in the pancreas, without significant complications. The apoptotic index of the tissue within 1 cm of the focus increased. Biochemical parameters were normal in all the dogs.
CONCLUSIONS
EUS-guided implantation of polymers is a safe, simple, and minimally invasive technique for interstitial chemotherapy in the pancreas.
背景与研究目的
已有报道采用手术植入的可生物降解聚合物进行间质化疗。本研究的目的是在犬模型中研究内镜超声（EUS）引导下胰腺间质化疗的可行性和安全性。
材料与方法
在EUS引导下，将一根带有大通道的19G治疗针插入胰腺。通过该针将用于5-氟尿嘧啶在肿瘤内持续释放的聚合物植入组织。经过14天的临床观察后，处死动物并检查组织对局部化疗的反应。
结果
所有聚合物均成功植入，未发生植入物迁移。胰腺实现了局部组织纤维性坏死，无明显并发症。病灶周围1厘米内组织凋亡指数增加。所有犬的生化指标均正常。
结论
EUS引导下聚合物植入是一种安全、简单且微创的胰腺间质化疗技术。
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