Kufer Thomas A
Molecular Innate Immunobiology Group, Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, Joseph-Stelzmann Str. 9, Geb. 37, Cologne, Germany.
Mol Biosyst. 2008 May;4(5):380-6. doi: 10.1039/b718948f. Epub 2008 Mar 27.
Proteins from the nucleotide-binding domain, LRR containing (NLR) family are involved in sensing bacterial invasion and danger signals in mammalian cells. Activation of these molecules leads to inflammatory responses which help clearance of invading pathogens. Recent data now shed light on the signal transduction pathways used by NLR proteins. This review summarizes advances in our understanding of signalling through NLRs with special emphasis on the Nod1 and Nod2 pathways.
来自含核苷酸结合结构域、富含亮氨酸重复序列（NLR）家族的蛋白质参与感知哺乳动物细胞中的细菌入侵和危险信号。这些分子的激活会引发炎症反应，有助于清除入侵的病原体。最近的数据揭示了NLR蛋白所使用的信号转导途径。本综述总结了我们对通过NLRs进行信号传导的理解进展，特别强调了Nod1和Nod2途径。
