Kersun L S, Reilly A F, Ingram M E, Nicholaou M J, McGowan K L
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Med Mycol. 2008 Jun;46(4):337-43. doi: 10.1080/13693780701874523.
Yeast infections cause morbidity in children with cancer and we evaluated species distribution and antifungal susceptibilities of the etiologic agents in this group. Specimens from 58 children yielded 64 cultures positive for yeasts. Central venous catheters were present in 56 (97%) of the children and neutrophil counts were <500 cells/ml3 in 34% of the patients. Twenty-two (38%) had received recent antifungal treatment, with 15 (25%) receiving fluconazole (FLU) prophylaxis. The Candida isolates recovered from four (27%) of the children on FLU prophylaxis, were resistant to this drug. Candida albicans isolates were susceptible to 100% of antifungals tested, whereas non-C. albicans Candida spp. were variable in their susceptibility patterns. FLU prophylaxis minimally affected susceptibility.
酵母菌感染会导致癌症患儿发病，我们评估了该群体中致病病原体的种类分布及抗真菌药敏情况。58名儿童的标本培养出64株酵母菌阳性。56名（97%）儿童有中心静脉导管，34%的患者中性粒细胞计数<500个细胞/毫升³。22名（38%）近期接受过抗真菌治疗，15名（25%）接受氟康唑（FLU）预防治疗。接受FLU预防治疗的4名（27%）儿童分离出的念珠菌对该药耐药。白色念珠菌分离株对所有测试抗真菌药物均敏感，而非白色念珠菌属念珠菌的药敏模式则各不相同。FLU预防治疗对药敏的影响极小。
