Bruder-Nascimento Ariane, Camargo Carlos Henrique, Sugizaki Maria Fátima, Sadatsune Terue, Montelli Augusto Cezar, Mondelli Alessandro Lia, Bagagli Eduardo
Botucatu Biosciences Institute, Sao Paulo State University, Botucatu, Brazil.
BMC Res Notes. 2010 Jan 3;3:1. doi: 10.1186/1756-0500-3-1.
Species identification and antifungal susceptibility tests were carried out on 212 Candida isolates obtained from bloodstream infections, urinary tract infections and dialysis-associated peritonitis, from cases attended at a Brazilian public tertiary hospital from January 1998 to January 2005.
Candida albicans represented 33% of the isolates, Candida parapsilosis 31.1%, Candida tropicalis 17.9%,Candida glabrata 11.8%, and others species 6.2%. In blood culture, C. parapsilosis was the most frequently encountered species (48%). The resistance levels to the antifungal azoles were relatively low for the several species, except for C. tropicalis and C. glabrata. Amphotericin B resistance was observed in 1 isolate of C. parapsilosis.
The species distribution and antifungal susceptibility herein observed presented several epidemiological features common to other tertiary hospitals in Latin American countries. It also exhibited some peculiarity, such as a very high frequency of C. parapsilosis both in bloodstream infections and dialysis-associated peritonitis. C. albicans also occurred in an important number of case infections, in all evaluated clinical sources. C. glabrata presented a high proportion of resistant isolates. The data emphasize the necessity to carry out the correct species identification accompanied by the susceptibility tests in all tertiary hospitals.
对1998年1月至2005年1月在巴西一家公立三级医院就诊的病例中，从血流感染、尿路感染和透析相关腹膜炎分离出的212株念珠菌进行了菌种鉴定和抗真菌药敏试验。
白色念珠菌占分离株的33%，近平滑念珠菌占31.1%，热带念珠菌占17.9%，光滑念珠菌占11.8%，其他菌种占6.2%。在血培养中，近平滑念珠菌是最常见的菌种（48%）。除热带念珠菌和光滑念珠菌外，几种菌种对唑类抗真菌药的耐药水平相对较低。在1株近平滑念珠菌中观察到对两性霉素B耐药。
本文观察到的菌种分布和抗真菌药敏情况呈现出拉丁美洲国家其他三级医院常见的一些流行病学特征。它也表现出一些特殊性，如近平滑念珠菌在血流感染和透析相关腹膜炎中出现的频率非常高。白色念珠菌在所有评估的临床来源的许多病例感染中也有出现。光滑念珠菌呈现出较高比例的耐药分离株。这些数据强调了在所有三级医院进行正确的菌种鉴定并同时进行药敏试验的必要性。
