原发性胃黏膜相关淋巴组织淋巴瘤：临床数据可预测治疗结果。
Primary gastric mucosa associated lymphoid tissue lymphoma: clinical data predicted treatment outcome.
作者信息
Todorovic Milena, Balint Bela, Jevtic Miodrag, Suvajdzic Nada, Ceric Amela, Stamatovic Dragana, Markovic Olivera, Perunicic Maja, Marjanovic Slobodan, Krstic Miodrag
机构信息
Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia.
出版信息
World J Gastroenterol. 2008 Apr 21;14(15):2388-93. doi: 10.3748/wjg.14.2388.
AIM
To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy.
METHODS
Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages I to IV) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo.
RESULTS
Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%.
CONCLUSION
Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.
目的
确定化疗及免疫化疗后胃淋巴瘤的临床特征及治疗结果。
方法
纳入34例原发性胃黏膜相关淋巴组织（MALT）淋巴瘤（Ann Arbor分期I至IV期）患者。所有患者均接受上消化道内镜检查、腹部超声、CT及幽门螺杆菌状态评估（组织学及血清学）。抗幽门螺杆菌治疗及初始化疗后，每4个月对患者进行复查。
结果
22/34例（64.7%）患者淋巴瘤组织学完全缓解，9例（26.5%）部分缓解。这31例缓解患者的中位随访时间为60个月（范围48 - 120个月）。3例患者无缓解。25例（73.5%）幽门螺杆菌阳性患者中，根除率为100%。
结论
单因素分析显示，总生存的预测因素为国际预后指数（IPI）评分、血红蛋白水平、红细胞沉降率（ESR）及血小板计数（P < 0.005）。此外，Cox比例风险模型将IPI评分、ESR及血小板作为生存预测因素。
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