Taizhou Central Hospital of Taizhou Enze Medical Group, Taizhou, China.
Int J Hematol. 2010 Jul;92(1):174-8. doi: 10.1007/s12185-010-0587-8. Epub 2010 May 12.
We describe two cases of primary gastric plasmacytoma (GP) associated with Helicobacter pylori infection. Case 1 was that of a 58-year-old man with epigastric pain. H. pylori was eradicated before surgical resection was performed, and after the therapy, the tumor size was reduced. A postoperative pathological examination revealed that the tumor was in early stage and histological grade was grade 1. After 44 months of operation, the patient was in complete remission with no evidence of local relapse or progression to systemic MM. Case 2 was that of a 70-year-old woman with a history of melena. H. pylori eradication was not presented preoperatively. The resected specimen showed the tumor was in advanced stage and histological grade 3. GP eventually progressed to MM and she died of pulmonary infection. In our opinion, GP cannot be eradicated with H. pylori eradication, but disease progression can be effectively controlled to a certain extent. The prognosis of this disease is relatively fair when treated at an early stage. In addition to the treatment, the difference in prognosis could be associated with age, the stage of the tumor, and histological grade.
我们描述了两例与幽门螺杆菌感染相关的原发性胃浆细胞瘤（GP）。病例 1 为 58 岁男性，表现为上腹痛。在进行手术切除前，我们进行了幽门螺杆菌根除治疗，治疗后肿瘤大小缩小。术后病理检查显示肿瘤处于早期，组织学分级为 1 级。术后 44 个月，患者完全缓解，无局部复发或进展为系统性多发性骨髓瘤的证据。病例 2 为 70 岁女性，有黑便史。术前未进行幽门螺杆菌根除治疗。切除标本显示肿瘤处于晚期，组织学分级为 3 级。GP 最终进展为 MM，死于肺部感染。我们认为，幽门螺杆菌根除不能消除 GP，但可以在一定程度上有效控制疾病进展。早期治疗时，该疾病的预后相对较好。除治疗外，预后的差异可能与年龄、肿瘤分期和组织学分级有关。
