对65例晚期不可切除肝细胞癌患者进行放射治疗。
Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma.
作者信息
Seo Yeon Seok, Kim Jin Nam, Keum Bora, Park Sanghoon, Kwon Yong Dae, Kim Yong Sik, Jeen Yoon Tae, Chun Hoon Jai, Kim Chul Yong, Kim Chang Duck, Ryu Ho Sang, Um Soon Ho
机构信息
Department of Internal Medicine, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Sungbuk-gu, Seoul 136-705, Korea.
出版信息
World J Gastroenterol. 2008 Apr 21;14(15):2394-400. doi: 10.3748/wjg.14.2394.
AIM
To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC).
METHODS
A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage II and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT.
RESULTS
The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, alpha-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m > or = 20% than in those with TRR1m < 20% (P < 0.001).
CONCLUSION
RT is effective in treating advanced HCC with a tumor response rate of 56.9%.
目的
评估放射治疗（RT）对晚期不可切除肝细胞癌（HCC）患者的疗效。
方法
韩国大学医学中心共有65例患者接受了RT治疗。患者的中位年龄为60岁，男性占86.2%。分别有18.5%和81.5%的患者被诊断为TNM分期II期和IV - A期。在RT开始4个月后评估治疗反应。还评估了RT开始1个月后的肿瘤退缩率（TRR1m）。从RT开始计算生存时间。
结果
客观治疗反应率为56.9%。12个月生存率为34.7%。生存的预测因素为Child - Pugh分级、甲胎蛋白水平和治疗反应。TRR1m≥20%的患者比TRR1m＜20%的患者更常获得客观反应（P＜0.001）。
结论
RT对晚期HCC有效，肿瘤反应率为56.9%。
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