Song Kyo-Young, Park Seung-Man, Kim Seung-Nam, Park Cho-Hyun
Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Am J Surg. 2008 Jul;196(1):19-22. doi: 10.1016/j.amjsurg.2007.05.056. Epub 2008 Apr 16.
The purpose of the current study was to determine the role of surgery in the treatment of recurrent gastric cancer.
Of the 347 patients with recurrent gastric cancer, 61 patients (17.8%) who underwent surgery were evaluated retrospectively. The underlying causes and types of surgery, survival, and postoperative quality of life were analyzed.
The most common cause of surgery was intestinal obstruction due to carcinomatosis. Complete resection was possible in 15 patients (24.6 %), including 10 gastric remnant recurrences, and 2 hepatic and 3 ovarian metastases. The survival of patients who had complete resection was significantly longer than the other groups (52.2 months for complete resections, 13.1 months for palliative procedures, and 8.7 months for laparotomy alone, respectively) (P < .05). The median hospital-free survival (HFS) durations were 9.4, 2.9, and 2.2 months for incomplete resection, bypass/enterostomy, and laparotomy only, respectively (P < .05).
Surgical treatment in recurrent gastric cancer is rarely indicated; however, if complete resection could be accomplished, long-term survival can be expected. Bypass surgery for symptom palliation did not increase the HFS.
本研究的目的是确定手术在复发性胃癌治疗中的作用。
回顾性评估了347例复发性胃癌患者中接受手术的61例患者(17.8%)。分析了手术的潜在原因和类型、生存率及术后生活质量。
手术的最常见原因是癌性腹膜炎导致的肠梗阻。15例患者(24.6%)实现了完全切除,包括10例胃残端复发、2例肝转移和3例卵巢转移。完全切除患者的生存期明显长于其他组(完全切除患者为52.2个月,姑息性手术患者为13.1个月,单纯剖腹手术患者为8.7个月)(P < 0.05)。不完全切除、旁路/肠造口术和单纯剖腹手术患者的中位无住院生存期(HFS)分别为9.4、2.9和2.2个月(P < 0.05)。
复发性胃癌很少需要手术治疗;然而,如果能实现完全切除,则有望获得长期生存。用于缓解症状的旁路手术并未增加HFS。