Mastrangelo G, Fadda E, Rylander R, Milan G, Fedeli U, Rossi di Schio M, Lange J H
Department of Environmental Medicine and Public Health, University of Padova, Via Giustinianai 2, 35128 Padova, Italy.
Occup Environ Med. 2008 Oct;65(10):697-700. doi: 10.1136/oem.2007.036327. Epub 2008 Apr 16.
Several studies report a lower than expected mortality in lung cancer among workers exposed to organic dust. Recent studies also reported a decreased risk for cancer at other sites.
To evaluate the mortality from lung and other cancer sites in cotton mill workers.
A cohort of 3961 Italian cotton mill workers was divided into those working with carding (exposed to high levels of endotoxin-containing cotton dust) and other tasks, which generally have lower exposure. Standardised mortality ratios (SMRs), with 95% confidence intervals (CI), were calculated using death rates of the regional general population as a reference. Cancer mortality was analysed in relation to the length of employment in the two task groups. An internal analysis was also performed through Poisson regression.
Among workers in carding departments, lung cancer SMRs were 1.88 (CI: 0.69 to 4.08), 1.01 (CI: 0.20 to 2.94) and 0.22 (CI: 0.00 to 1.24), respectively, for <6, 6-12 and >12 years of employment (chi(2) for trend = 5.45; p<0.05). A significant (p = 0.04) trend was confirmed by Poisson regression. No reduced risks were found for other forms of cancer, nor for those working with other tasks.
The results support previous reports that a high and prolonged exposure to cotton dust and other endotoxin-containing organic dusts is related to a lower risk of lung cancer. There was no indication of a reduced risk for other forms of cancer.
多项研究报告称，接触有机粉尘的工人肺癌死亡率低于预期。近期研究还报告了其他部位患癌风险降低。
评估棉纺织厂工人肺癌及其他癌症部位的死亡率。
将3961名意大利棉纺织厂工人队列分为从事梳棉工作（接触高浓度含内毒素棉尘）的工人和其他工作的工人，后者接触水平通常较低。以地区总人口死亡率为参照，计算标准化死亡比（SMR）及95%置信区间（CI）。分析两个工作组的癌症死亡率与就业时长的关系。还通过泊松回归进行了内部分析。
在梳棉部门工作的工人中，就业时长<6年、6 - 12年和>12年的肺癌SMR分别为1.88（CI：0.69至4.08）、1.01（CI：0.20至2.94）和0.22（CI：0.00至1.24）（趋势χ² = 5.45；p<0.05）。泊松回归证实了显著趋势（p = 0.04）。未发现其他癌症形式以及从事其他工作的工人患癌风险降低。
研究结果支持先前报告，即长期大量接触棉尘和其他含内毒素有机粉尘与较低的肺癌风险相关。未显示其他癌症形式的风险降低迹象。
