Huang Xinru
School of Management, Xuzhou Medical University.
School of International Education, Xuzhou Kindergarten Teachers College, Xuzhou, Jiangsu, China.
Medicine (Baltimore). 2020 Apr;99(14):e19565. doi: 10.1097/MD.0000000000019565.
Findings on the association between cotton dust exposure and lung cancer risk in epidemiologic studies have been inconsistent. Therefore, we conducted a meta-analysis of data from observational studies to quantify this association.PubMed, EMBASE, and the Cochrane library databases were searched for observational studies with data on cotton dust exposure and lung cancer risk. Studies that reported adjusted relative risks (RRs) with 95% confidence intervals (CIs) of lung cancer associated with cotton dust exposure were included. Subgroup analyses were conducted according to key characteristics.Fifteen studies involving a total of 73,812 individuals were included in the meta-analysis. Combining estimates from all the 15 observational studies, cotton dust exposure was associated with a decreased risk of lung cancer (combined RR, 0.78; 95% CI, 0.66-0.91; P = .002). Pooled estimates of multivariate RRs by gender were 0.71 (95% CI, 0.58-0.88; P = .001) among males, based on 7 studies, and 0.77 (95% CI, 0.67-0.89; P < .001) among females, based on 9 studies. Further analyses examining the influence of a single study on the results by omitting a study at each turn yielded a range of RR from 0.74 to 0.82.Our meta-analysis indicates that cotton dust exposure is associated with a decreased risk of lung cancer.
流行病学研究中关于接触棉尘与肺癌风险之间关联的结果并不一致。因此，我们对观察性研究的数据进行了荟萃分析，以量化这种关联。我们在PubMed、EMBASE和Cochrane图书馆数据库中检索了有关棉尘接触和肺癌风险数据的观察性研究。纳入报告了与棉尘接触相关的肺癌调整相对风险（RRs）及95%置信区间（CIs）的研究。根据关键特征进行亚组分析。荟萃分析纳入了15项研究，共涉及73812名个体。综合15项观察性研究的估计值，接触棉尘与肺癌风险降低相关（合并RR，0.78；95%CI，0.66 - 0.91；P = 0.002）。基于7项研究，男性多元RR的合并估计值为0.71（95%CI，0.58 - 0.88；P = 0.001），基于9项研究，女性为0.77（95%CI，0.67 - 0.89；P < 0.001）。通过每次剔除一项研究来进一步分析单项研究对结果的影响，得出的RR范围为0.74至0.82。我们的荟萃分析表明，接触棉尘与肺癌风险降低相关。
