Brunetti Natale Daniele, Pepe Martino, Munno Irene, Tiecco Fabio, Quagliara Donato, De Gennaro Luisa, Gaglione Antonio, Di Biase Matteo, Favale Stefano
Cardiology Department, University of Foggia, Italy.
Coron Artery Dis. 2008 May;19(3):133-7. doi: 10.1097/MCA.0b013e3282f3fbcb.
The aim of this study is to investigate the T helper (Th)2-dependent release of interleukin(IL)-4 and IL-13 in patients with unstable angina treated with coronary angioplasty (PCI).
This study involved 48 consecutive patients with unstable angina who underwent PCI. Blood samples were taken before and 48 h after PCI to evaluate serum IL-4 and IL-13 levels. Coronary atherosclerosis was assessed in terms of the severity of the treated lesions and the presence of multivessel disease, and compared with IL release.
Before and after PCI, serum IL-4 levels were, respectively, 53.1+/-110.7 and 35.1+/-16.9 pg/ml (P not significant), and serum IL-13 levels 6.7+/-3.7 and 6.0+/-2.9 pg/ml (P<0.05). A correlation was present between the severity of the treated coronary lesions and serum IL-13 levels (r 0.36; P<0.05). The patients with multivessel coronary artery disease had a higher periprocedure ratio of IL-4 than those with single-vessel coronary artery disease (1.46+/-0.76 vs. 0.89+/-0.34, P<0.001).
A significant decrease was observed in Th2-dependent IL concentrations after PCI; increased Th2-dependent IL levels before PCI seem to correlate with the severity of coronary atherosclerosis.
本研究旨在调查经皮冠状动脉介入治疗（PCI）的不稳定型心绞痛患者中辅助性T细胞（Th）2依赖的白细胞介素（IL）-4和IL-13的释放情况。
本研究纳入了48例连续接受PCI的不稳定型心绞痛患者。在PCI术前和术后48小时采集血样，以评估血清IL-4和IL-13水平。根据治疗病变的严重程度和多支血管病变的存在情况评估冠状动脉粥样硬化，并与IL释放情况进行比较。
PCI术前和术后，血清IL-4水平分别为53.1±110.7和35.1±16.9 pg/ml（P无统计学意义），血清IL-13水平分别为6.7±3.7和6.0±2.9 pg/ml（P<0.05）。治疗的冠状动脉病变严重程度与血清IL-13水平之间存在相关性（r = 0.36；P<0.05）。多支冠状动脉疾病患者围手术期IL-4比值高于单支冠状动脉疾病患者（1.46±0.76 vs. 0.89±0.34，P<0.001）。
PCI术后观察到Th2依赖的IL浓度显著降低；PCI术前Th2依赖的IL水平升高似乎与冠状动脉粥样硬化的严重程度相关。
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