Zhao Chang-Qing, Gu Hong-Tu, Cheng Yang
Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jan;28(1):24-7.
To study the clinical effects of Fuzheng Huayu Gantang comprehensive therapeutic program (FHGP) on post-hepatitis B liver cirrhosis associated with glyco-metabolic abnormality (LCGA).
The patients with LCGA enrolled in the randomized controlled clinical trial were assigned to 2 groups, the treated group (68 cases) and the control group (74 cases), they were treated respectively by FHGP and conventional TCM and Western medicine therapeutic program for 3 months. Indexes including fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2 h PG), fasting insulin (FINS) were detected, homeostasis model assessment insulin resistance (HOMA-IR) was calculated, and the score of syndrome was recorded before and after treatment. Then the effects on syndrome and glyco-metabolic abnormality were evaluated through statistical analysis.
Level of 2 h PG after treatment was lowered in both groups (P < 0.01), but significant difference was found in the pre-treatment to post-treatment decrement of FPG and HOMA-IR between the two groups (P < 0.05). The syndrome improving rate and the total effective rate on glyco-metabolic abnormality in the treated group were significantly better than those in the control group respectively (85.3% vs 64.9% , P < 0.01; 80.9% vs 62.2%, P < 0.05).
FHGP has the capability to improve the syndrome and glyco-metabolic abnormality of patients with LCGA.
探讨扶正化瘀肝糖方综合治疗方案（FHGP）对乙型肝炎后肝硬化合并糖代谢异常（LCGA）的临床疗效。
将纳入随机对照临床试验的LCGA患者分为2组，治疗组（68例）和对照组（74例），分别采用FHGP和传统中西医结合治疗方案治疗3个月。检测空腹血糖（FPG）、餐后2小时血糖（2h PG）、空腹胰岛素（FINS）等指标，计算稳态模型评估胰岛素抵抗（HOMA-IR），记录治疗前后证候积分。通过统计学分析评价对证候及糖代谢异常的影响。
两组治疗后2h PG水平均降低（P<0.01），但两组FPG及HOMA-IR治疗前后下降幅度差异有统计学意义（P<0.05）。治疗组证候改善率及糖代谢异常总有效率分别显著优于对照组（85.3%对64.9%，P<0.01；80.9%对62.2%，P<0.05）。
FHGP能改善LCGA患者的证候及糖代谢异常。
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