尿道下裂、隐睾症、肛门生殖器距离与内分泌干扰之间的关联。
Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption.
作者信息
Hsieh Michael H, Breyer Benjamin N, Eisenberg Michael L, Baskin Laurence S
机构信息
Scott Department of Urology, Texas Children's Hospital, Clinical Care Center, Baylor College of Medicine, Suite 660, 6621 Fannin Street, Houston, TX 77030, USA.
出版信息
Curr Urol Rep. 2008 Mar;9(2):137-42. doi: 10.1007/s11934-008-0025-0.
Endocrine disruptors, such as environmental compounds with endocrine-altering properties, may cause hypospadias and cryptorchidism in several species, including humans. Anogenital distance is sexually dimorphic in many mammals, with males having longer anogenital distance on average than females. Animal models of proposed endocrine disruptors have associated prenatal exposure with hypospadias, cryptorchidism, and reduced anogenital distance. Human studies have correlated shorter anogenital distance to in utero exposure to putative endocrine disruptors. We review preliminary data suggesting that anogenital distance is reduced in boys with hypospadia and cryptorchidism. Hence, human hypospadias and cryptorchidism may be associated with reduced anogenital distance as a result of endocrine disruption.
内分泌干扰物，如具有改变内分泌特性的环境化合物，可能会在包括人类在内的多个物种中导致尿道下裂和隐睾症。在许多哺乳动物中，肛门与生殖器之间的距离存在性别差异，雄性的平均肛门与生殖器之间的距离比雌性更长。拟议的内分泌干扰物的动物模型已将产前暴露与尿道下裂、隐睾症以及肛门与生殖器之间距离缩短联系起来。人体研究已将较短的肛门与生殖器之间的距离与子宫内暴露于假定的内分泌干扰物相关联。我们回顾了初步数据，这些数据表明尿道下裂和隐睾症男孩的肛门与生殖器之间的距离缩短。因此，人类的尿道下裂和隐睾症可能由于内分泌干扰而与肛门与生殖器之间的距离缩短有关。
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