对轮状威尔布兰迪亚（c.f.）纯化部分的抗肿瘤活性评估。

Evaluation of the purified fraction of Wilbrandia (c.f.) verticillata for antitumour activity.

作者信息

Rao V S, Almeida F R, Moraes A P, Silva J V, Nascimento S C, Moraes M O

机构信息

Departamento de Fisiologia e Farmacologia, UFC, Fortaleza, CE, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:43-5. doi: 10.1590/s0074-02761991000600012.

DOI:10.1590/s0074-02761991000600012

PMID:1842011

Abstract

Cucurbitacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wv1 and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and antitumour activities of these norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12 micrograms/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).

摘要

已知葫芦素具有细胞毒性和抗癌活性。最近从轮状威尔布氏草根茎的纯化组分中分离出两种新型降葫芦素糖苷（Wv1和Wv2）。本研究评估了这些降葫芦素的细胞毒性和抗肿瘤活性。我们发现其对KB细胞具有一定的细胞毒性（半数细胞毒性浓度Cy50 = 12微克/毫升），并且对Walker 256癌肉瘤的生长有显著抑制作用（约75%）。