加斯曼分子内[2+2]阳离子环加成反应。瑞考韦纳尔和表瑞考韦纳尔的形式全合成。

Gassman's intramolecular [2 + 2] cationic cycloaddition. formal total syntheses of raikovenal and epi-raikovenal.

作者信息

Ko Changhong, Feltenberger John B, Ghosh Sunil K, Hsung Richard P

机构信息

Division of Pharmaceutical Sciences and Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, Wisconsin 53705-2222, USA.

出版信息

Org Lett. 2008 May 15;10(10):1971-4. doi: 10.1021/ol8004968. Epub 2008 Apr 19.

DOI:10.1021/ol8004968

PMID:18422320

Abstract

The first intramolecular version of Gassman's cationic [2 + 2] cycloaddition employing vinyl acetals tethered to an unactivated olefin and its application in the formal syntheses of raikovenal and epi-raikovenal are described.

摘要

描述了加斯曼阳离子型分子内[2+2]环加成反应的首个实例，该反应使用与未活化烯烃相连的乙烯基缩醛，及其在雷科韦纳尔和表雷科韦纳尔的形式合成中的应用。