Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN 47405, USA.
Nat Prod Rep. 2019 Oct 16;36(10):1383-1393. doi: 10.1039/c8np00083b.
Covering: January 2000 to July 2018 gem-Dimethylcyclobutanes are a common motif found in a multitude of natural products, and thus these structures have captivated synthetic chemists for years. However, until the turn of the century, most synthetic efforts relied upon the use of widely available terpenes, such as pinene or caryophyllene, that already contain the gem-dimethylcyclobutane motif. This approach limits the scope of molecules that can be accessed readily. This review highlights recent syntheses in which the gem-dimethylcyclobutane is assembled via de novo approaches. An outlook on the future of this research area is also provided.
2000 年 1 月至 2018 年 7 月
gem-二甲基环丁烷是多种天然产物中常见的结构基序，因此这些结构多年来一直吸引着合成化学家。然而，直到本世纪初，大多数合成工作都依赖于广泛可用的萜烯，如蒎烯或石竹烯，它们已经包含了 gem-二甲基环丁烷基序。这种方法限制了可以轻易获得的分子的范围。本综述重点介绍了通过从头合成方法组装 gem-二甲基环丁烷的最新合成方法。还对该研究领域的未来进行了展望。
