铜催化酮类合成酯。烷基作为离去基团。

Copper-catalyzed synthesis of esters from ketones. Alkyl group as a leaving group.

作者信息

Nakatani Yuji, Koizumi Yuichiro, Yamasaki Ryu, Saito Shinichi

机构信息

Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku, Tokyo 162-8601, Japan.

出版信息

Org Lett. 2008 May 15;10(10):2067-70. doi: 10.1021/ol800576w. Epub 2008 Apr 19.

DOI:10.1021/ol800576w

PMID:18422324

Abstract

The conversion of ketones to esters has been achieved through the use of Cu catalyst and tetrabutylammonium nitrite. This reaction involves the activation of the less activated C-C bond, and the alkyl group is removed as a leaving group. Various isopropyl ketones are found to be good substrates for this reaction.

摘要

通过使用铜催化剂和亚硝酸四丁铵，已实现了酮向酯的转化。该反应涉及活性较低的碳 - 碳键的活化，烷基作为离去基团被除去。发现各种异丙基酮都是该反应的良好底物。