Rujner J, Socha J, Janas R, Woźniewicz B
Department of Gastronenterology, Child Health Centre, Warszawa, Poland.
Mater Med Pol. 1991 Oct-Dec;23(4):267-72.
In 31 children with congenital alpha 1-antitrypsin deficiency the concentration of procollagen type III peptide was determined in a trial establishing liver fibrosis degree and monitoring of fibrosis progression. No correlation was found between the degree liver fibrosis determined by histological examination and the serum concentration of procollagen type III peptide. The concentration of procollagen type III peptide was higher with coexistent cholestasis and in case of inflammatory processes outside the liver (pneumonia). In progressing cirrhosis with inflammatory reaction the concentration was higher than in advanced cirrhosis and non-inflammatory liver fibrosis.
在一项确定肝纤维化程度并监测纤维化进展的试验中，对31名先天性α1 -抗胰蛋白酶缺乏症患儿的III型前胶原肽浓度进行了测定。组织学检查确定的肝纤维化程度与血清III型前胶原肽浓度之间未发现相关性。在合并胆汁淤积以及存在肝脏外炎症过程（肺炎）的情况下，III型前胶原肽浓度较高。在伴有炎症反应的进行性肝硬化中，该浓度高于晚期肝硬化和非炎性肝纤维化。
