Karlsson K K, Berninger E, Alván G
Department of Audiology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Scand Audiol. 1991;20(2):83-90. doi: 10.3109/01050399109070795.
Quinine causes reversible hearing loss, closely related to the quinine plasma concentration. The effects of quinine on psychoacoustic tuning curves, stapedius reflex thresholds and evoked otoacoustic emissions were studied in healthy volunteers. The tuning curves became shallower, whereas reflex thresholds were unaffected. The shift in the emission thresholds paralleled that of the pure-tone thresholds. There were also qualitative changes in the emissions: 1) the exponent of the stimulus-response function changed from 0.34 to 0.56; 2) decay time shortened; 3) the power spectrum shifted towards lower frequencies. The results are discussed in relation to various aspects of cochlear performance and are suggested to depend on an outer hair cell dysfunction.
奎宁会导致可逆性听力损失，这与血浆中奎宁的浓度密切相关。在健康志愿者中研究了奎宁对心理声学调谐曲线、镫骨肌反射阈值和诱发耳声发射的影响。调谐曲线变得更浅，而反射阈值未受影响。耳声发射阈值的变化与纯音阈值的变化平行。耳声发射也有质的变化：1）刺激-反应函数的指数从0.34变为0.56；2）衰减时间缩短；3）功率谱向低频方向移动。结合耳蜗功能的各个方面对结果进行了讨论，并认为这些结果取决于外毛细胞功能障碍。
