Berninger E, Karlsson K K, Alván G
Department of Audiology, Karolinska Institute, Huddinge University Hospital, Sweden.
Acta Otolaryngol. 1998 Jan;118(1):46-51.
The aim of the study was to evaluate and quantify quinine-induced changes in the human auditory dynamic range, as a model for cochlear hearing loss. Six otologically normal volunteers (21-40 years old) received quinine hydrochloride (15 mg/kg body weight) in two identical oral doses and one intravenous infusion. Refined hearing tests were performed monaurally at threshold, at moderate hearing levels and at high hearing levels. Quinine induced a maximal pure-tone threshold shift of 23 dB (1000-2000 Hz). The increase in the psychoacoustical click threshold agreed with an increase in the detection threshold of click-evoked otoacoustic emissions. The change in the stimulus-response relationship of the emissions reflected recruitment. The self-attained most comfortable speech level and the acoustic stapedius reflex thresholds were not affected by quinine administration. Quinine is a useful model substance for reversibly inducing complete loudness recruitment in humans as it acts specifically on some parts of the hearing function. Its mechanism of action on the molecular level is likely to reveal further information on the physiology of hearing.
本研究的目的是评估和量化奎宁引起的人类听觉动态范围变化，以此作为耳蜗性听力损失的模型。六名听力正常的志愿者（21 - 40岁）接受了两次相同口服剂量及一次静脉输注的盐酸奎宁（15毫克/千克体重）。在阈值、中度听力水平和高度听力水平下对单耳进行了精细的听力测试。奎宁引起的最大纯音阈值偏移为23分贝（1000 - 2000赫兹）。心理声学短声阈值的增加与短声诱发耳声发射检测阈值的增加一致。耳声发射刺激 - 反应关系的变化反映了重振现象。自我获得的最舒适言语水平和镫骨肌声反射阈值不受奎宁给药的影响。奎宁是一种有用的模型物质，可在人类中可逆地诱导完全响度重振，因为它特异性作用于听力功能的某些部分。其在分子水平上的作用机制可能会揭示有关听力生理学的更多信息。
