Wahn U, Warner J, Simons F E R, de Benedictis F M, Diepgen T L, Naspitz C K, de Longueville M, Bauchau V
Pneumologie und Immunologie, University Kinder & Poliklinik Klinik für Pädiatrie mit Schwerpunkt, Berlin, Germany.
Pediatr Allergy Immunol. 2008 Jun;19(4):332-6. doi: 10.1111/j.1399-3038.2007.00643.x. Epub 2008 Apr 16.
In 2184 young children aged 13-24 months with atopic dermatitis (SCORAD 5-59) serum IgE antibodies to a standard panel of food and inhalant allergens were assayed. The frequency of positive IgE responses (>0.35 kU/l) increased with greater severity of skin disease. A significant minority of infants had levels of IgE antibody to foods to suggest they were at risk of acute reaction to those foods (7% to hen's egg, 3% to cow's milk, 4% to peanut). Our findings indicate that the frequency of positive IgE responses is related to disease severity and suggest that differences in the time course of the development of IgE responses to food, which are at maximum prevalence within the first year of life, while inhalant allergies, are still developing between 1 and 2 yr and beyond.
在2184名患有特应性皮炎（SCORAD评分5 - 59）的13至24个月大的幼儿中，检测了其针对一组标准食物和吸入性过敏原的血清IgE抗体。IgE阳性反应（>0.35 kU/l）的频率随皮肤疾病严重程度的增加而升高。少数婴儿的食物IgE抗体水平表明他们有对这些食物发生急性反应的风险（对鸡蛋为7%，对牛奶为3%，对花生为4%）。我们的研究结果表明，IgE阳性反应的频率与疾病严重程度相关，并提示对食物的IgE反应在生命的第一年患病率最高，而吸入性过敏在1至2岁及以后仍在发展，两者在IgE反应发展的时间进程上存在差异。
