Plachokova Adelina S, Nikolidakis Dimitris, Mulder Jan, Jansen John A, Creugers Nico H J
Department of Periodontology & Biomaterials, College of Dental Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Clin Oral Implants Res. 2008 Jun;19(6):539-45. doi: 10.1111/j.1600-0501.2008.01525.x. Epub 2008 Apr 16.
To review systematically the reported effects of platelet-rich plasma (PRP) on bone regeneration.
Up to June 2006, MEDLINE and Cochrane databases were explored with different combinations of three search terms: 'PRP', 'bone regeneration', 'dentistry' and their synonyms.
human controlled clinical trials designed to treat maxillofacial bony defects with application of PRP (test) or without PRP (control), including at least five patients with a follow-up period of more than 3 months and using clinical assessment, radiography, histology and/or histomorphometry for evaluation. Literature search, selection of eligible articles and data extraction were carried out independently by two readers.
The literature search revealed 108 references, of which 17 were selected for further analysis. Finally, nine articles fulfilling the inclusion criteria were selected for systematically review. Owing the substantial heterogeneity of the studies it was not possible to analyze the data statistically. An attempt was made to compare results from studies that used similar outcome measures by calculating and adding confidence intervals to the data presented in the original papers. Differences in treatment effects for periodontal defects in terms of clinical attachment level (CAL) were significant (ranging from 0.8 to 3.2 mm). The reported effects of PRP in sinus elevation (compared with their controls) were <10%.
We found evidence for beneficial effects of PRP in the treatment of periodontal defects. Evidence for beneficial effects of PRP in sinus elevation appeared to be weak. No conclusions can be drawn about other applications of PRP in dentistry.
系统回顾已报道的富血小板血浆（PRP）对骨再生的影响。
截至2006年6月，利用“PRP”“骨再生”“牙科”及其同义词这三个检索词的不同组合，对MEDLINE和Cochrane数据库进行检索。
旨在采用PRP（试验组）或不采用PRP（对照组）治疗颌面部骨缺损的人体对照临床试验，包括至少5例患者，随访期超过3个月，并采用临床评估、影像学、组织学和/或组织形态计量学进行评估。文献检索、合格文章的筛选和数据提取由两位读者独立进行。
文献检索共找到108篇参考文献，其中17篇被选作进一步分析。最终，9篇符合纳入标准的文章被选作系统评价。由于研究存在较大异质性，无法对数据进行统计学分析。尝试通过计算并在原始论文呈现的数据中添加置信区间，比较采用相似结局指标的研究结果。在牙周缺损的临床附着水平（CAL）方面，治疗效果差异显著（范围为0.8至3.2毫米）。PRP在窦提升术中（与对照组相比）的报道效果<10%。
我们发现有证据表明PRP在治疗牙周缺损方面有有益作用。PRP在窦提升术中有益作用的证据似乎较弱。关于PRP在牙科的其他应用无法得出结论。
