Huang Tsung-Hsi, Chen Jui-Yi, Suo Wei-Hsin, Shao Wen-Rou, Huang Chih-Ying, Li Ming-Tse, Li Yu-Ying, Li Yuan-Hong, Liang En-Lun, Chen Yu-Hsu, Lee I-Ta
Department of Orthopedic Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan.
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
Biomedicines. 2024 May 14;12(5):1090. doi: 10.3390/biomedicines12051090.
Periodontal defects present a significant challenge in dentistry, necessitating innovative solutions for comprehensive regeneration. Traditional restoration methods have inherent limitations in achieving complete and functional periodontal tissue reconstruction. Tissue engineering, a multidisciplinary approach integrating cells, biomaterials, and bioactive factors, holds tremendous promise in addressing this challenge. Central to tissue engineering strategies are scaffolds, pivotal in supporting cell behavior and orchestrating tissue regeneration. Natural and synthetic materials have been extensively explored, each offering unique advantages in terms of biocompatibility and tunable properties. The integration of growth factors and stem cells further amplifies the regenerative potential, contributing to enhanced tissue healing and functional restoration. Despite significant progress, challenges persist. Achieving the seamless integration of regenerated tissues, establishing proper vascularization, and developing biomimetic scaffolds that faithfully replicate the natural periodontal environment are ongoing research endeavors. Collaborative efforts across diverse scientific disciplines are essential to overcoming these hurdles. This comprehensive review underscores the critical need for continued research and development in tissue engineering strategies for periodontal regeneration. By addressing current challenges and fostering interdisciplinary collaborations, we can unlock the full regenerative potential, paving the way for transformative advancements in periodontal care. This research not only enhances our understanding of periodontal tissues but also offers innovative approaches that can revolutionize dental therapies, improving patient outcomes and reshaping the future of periodontal treatments.
牙周缺损在牙科领域是一项重大挑战，需要创新解决方案来实现全面再生。传统修复方法在实现完整且功能正常的牙周组织重建方面存在固有局限性。组织工程作为一种整合细胞、生物材料和生物活性因子的多学科方法，在应对这一挑战方面具有巨大潜力。组织工程策略的核心是支架，它对于支持细胞行为和协调组织再生至关重要。天然材料和合成材料都已得到广泛探索，它们在生物相容性和可调节特性方面各自具有独特优势。生长因子和干细胞的整合进一步增强了再生潜力，有助于促进组织愈合和功能恢复。尽管取得了重大进展，但挑战依然存在。实现再生组织的无缝整合、建立适当的血管化以及开发能够忠实地复制天然牙周环境的仿生支架仍是正在进行的研究工作。跨不同科学学科的合作努力对于克服这些障碍至关重要。这篇全面综述强调了在牙周再生组织工程策略方面持续研发的迫切需求。通过应对当前挑战并促进跨学科合作，我们能够释放全部再生潜力，为牙周护理的变革性进展铺平道路。这项研究不仅增进了我们对牙周组织的理解，还提供了能够彻底改变牙科治疗的创新方法，改善患者预后并重塑牙周治疗的未来。
