促卵泡激素和促黄体生成素对吲哚美辛处理的大鼠体内卵巢环磷酸腺苷和前列腺素E的影响。

Effects of follicle-stimulating hormone and luteinizing hormone on ovarian cyclic AMP and prostaglandin E in vivo in rats treated with indomethacin.

作者信息

Rigler G L, Peake G T, Ratner A

出版信息

J Endocrinol. 1976 Aug;70(2):285-91. doi: 10.1677/joe.0.0700285.

DOI:10.1677/joe.0.0700285

Abstract

The role of prostaglandins in both FSH- and LH-mediated increases in ovarian cyclic AMP was examined in rats in vivo. Dose-related increases in ovarian cyclic AMP levels were observed 10 min after intravenous injection of FSH or LH. No changes in ovarian prostaglandin E (PGE) content were detected after injection of either gonadotrophin at doses which substantially enhanced cyclic AMP accumulation. Prior treatment of rats with indomethacin produced a greater than 50% decrease in ovarian PGE levels, but did not prevent the FSH- or LH-induced rise in ovarian cyclic AMP concentration. These in vivo experiments do not support the concept that PGE plays a role as an obligatory mediator for the gonadotrophin-induced rise in ovarian cyclic AMP levels.

摘要

在体内实验中，研究了前列腺素在促卵泡激素（FSH）和促黄体生成素（LH）介导的卵巢环磷酸腺苷（cAMP）增加中的作用。静脉注射FSH或LH 10分钟后，观察到卵巢cAMP水平呈剂量相关增加。在注射能显著增强环磷酸腺苷积累的剂量的促性腺激素后，未检测到卵巢前列腺素E（PGE）含量的变化。用吲哚美辛预先处理大鼠后，卵巢PGE水平降低了50%以上，但并未阻止FSH或LH诱导的卵巢cAMP浓度升高。这些体内实验不支持PGE作为促性腺激素诱导的卵巢cAMP水平升高的必需介质发挥作用这一概念。