Youn Byung Jae, Chung Jin Wook, Son Kyu Ri, Kim Hyo-Cheol, Jae Hwan Jun, Lee Jeong Min, Song In Chan, Kim In-One, Park Jae Hyung
Department of Radiology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea.
Acad Radiol. 2008 May;15(5):593-600. doi: 10.1016/j.acra.2007.10.022.
The study goal was to evaluate the ability of diffusion-weighted imaging (DWI) in assessing the viability of rabbit liver VX-2 tumor after transcatheter arterial chemoembolization (TACE).
VX-2 tumors were grown in the livers of 19 rabbits, and chemoembolization was performed. MR imaging was acquired 1 week after TACE. The rabbits were killed for histologic investigation immediately after MR imaging, and the proportion of viable tumor was calculated based on histopathologic examination. Apparent diffusion coefficient (ADC) values were measured in viable and necrotic tumor portion, and were compared using the paired Student's t test.
Viable tumors were absent (n = 3), less than 5% (n = 6), and 5% or more (n = 10) at pathology examination. On DWI, three tumors with no viable portion were interpreted as having no viable portion, but three of six tumors with a viable portion of less than 5% were considered as having no viable portion. The mean ADC values of necrotic and viable tumor were 1.653 +/- 0.126 mm(2)/sec and 0.883 +/- 0.407 mm(2)/sec (b = 1000 sec/mm(2)), respectively, and the ADC values of necrotic tumors were significantly greater than those in viable tumors (p < .01).
Although DWI is a useful tool for assessing tumor viability, viable tumor may not be detected on DWI when it is too small.
本研究旨在评估弥散加权成像（DWI）在经导管动脉化疗栓塞术（TACE）后评估兔肝VX-2肿瘤存活情况的能力。
在19只兔的肝脏中种植VX-2肿瘤，并进行化疗栓塞。TACE术后1周进行磁共振成像。磁共振成像后立即处死兔子进行组织学检查，并根据组织病理学检查计算存活肿瘤的比例。在存活和坏死肿瘤部分测量表观扩散系数（ADC）值，并使用配对t检验进行比较。
病理检查时，无存活肿瘤（n = 3）、存活肿瘤小于5%（n = 6）、存活肿瘤为5%或更多（n = 10）。在DWI上，3个无存活部分的肿瘤被判定为无存活部分，但6个存活部分小于5%的肿瘤中有3个被认为无存活部分。坏死和存活肿瘤的平均ADC值分别为1.653±0.126mm²/sec和0.883±0.407mm²/sec（b = 1000sec/mm²），坏死肿瘤的ADC值显著高于存活肿瘤（p < 0.01）。
尽管DWI是评估肿瘤存活情况的有用工具，但当存活肿瘤过小时，DWI可能无法检测到。
