Maurage P, Campanella S, Philippot P, de Timary P, Constant E, Gauthier S, Miccichè M-L, Kornreich C, Hanak C, Noel X, Verbanck P
Unité NESC, Faculté de Psychologie, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Neurophysiol Clin. 2008 Apr;38(2):83-97. doi: 10.1016/j.neucli.2008.02.001. Epub 2008 Mar 3.
Alcoholism is associated with a deficit in the processing of emotional facial expressions (EFE) and with a delayed P3b component, partially mediated by earlier perceptive deficits (P100, N170). Since alcohol dependence often occurs with depression, we aim at investigating whether classical event-related potentials (ERP) alterations observed in alcoholism are modulated or not by depression.
Four groups (controls; alcoholics; depressed; alcoholics-depressed) of 12 participants performed two different discrimination tasks, a gender and an emotional one. They had to decide as quickly as possible about the gender or the emotion displayed by facial stimuli during an ERP recording session (32 channels). Reaction times (RTs), P100, N100, N170 and P3b were recorded.
At the behavioural level, control participants discriminated EFE (but not gender) more rapidly than the three other groups. At the ERP level, the differences observed on RTs for emotional task were neurophysiologically indexed by a delayed P3b component. This delay was associated with earlier ERP alterations (P100, N100, N170), but only in participants suffering from alcohol dependence, in association or not with depression.
On the one hand, individuals with alcoholism, associated or not with a comorbid depression, were impaired in the processing of EFE. This deficit was neurophysiologically indexed by early perceptive (P100, N100, N170) and decisional (P3b) alterations. On the other hand, non-alcoholic patients with depression only exhibited P3b impairment. These results lead to potential implications concerning the usefulness of the ERP for the differential diagnosis in psychiatry, notably concerning the comorbidities in alcoholism.
酒精中毒与情绪性面部表情（EFE）加工缺陷以及P3b成分延迟有关，部分是由早期感知缺陷（P100、N170）介导的。由于酒精依赖常与抑郁症并发，我们旨在研究酒精中毒中观察到的经典事件相关电位（ERP）改变是否受抑郁症调节。
四组（对照组；酒精中毒者；抑郁症患者；酒精中毒合并抑郁症患者），每组12名参与者，进行两项不同的辨别任务，一项是性别辨别任务，另一项是情绪辨别任务。在ERP记录过程中（32个通道），他们必须尽快判断面部刺激所显示的性别或情绪。记录反应时间（RTs）、P100、N100、N170和P3b。
在行为水平上，对照组参与者辨别EFE（而非性别）的速度比其他三组更快。在ERP水平上，情绪任务中RTs上观察到的差异在神经生理学上表现为P3b成分延迟。这种延迟与早期ERP改变（P100、N100、N170）有关，但仅在患有酒精依赖的参与者中出现，无论是否合并抑郁症。
一方面，患有酒精中毒的个体，无论是否合并共病抑郁症，在EFE加工方面都存在缺陷。这种缺陷在神经生理学上表现为早期感知（P100、N100、N170）和决策（P3b）改变。另一方面，非酒精性抑郁症患者仅表现出P3b受损。这些结果对ERP在精神病学鉴别诊断中的有用性具有潜在意义，特别是在酒精中毒共病方面。
