脂联素可增加内皮祖细胞数量并增强其功能。
Adiponectin promotes endothelial progenitor cell number and function.
作者信息
Shibata Rei, Skurk Carsten, Ouchi Noriyuki, Galasso Gennaro, Kondo Kazuhisa, Ohashi Taiki, Shimano Masayuki, Kihara Shinji, Murohara Toyoaki, Walsh Kenneth
机构信息
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
出版信息
FEBS Lett. 2008 May 14;582(11):1607-12. doi: 10.1016/j.febslet.2008.04.006. Epub 2008 Apr 16.
Abstract
Obesity-linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose-derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPCs. EPC levels did not increase in adiponectin deficient (APN-KO) in response to hindlimb ischemia. Adenovirus-mediated delivery of adiponectin increased EPC levels in both WT and APN-KO mice. Incubation of human peripheral blood mononuclear cells with adiponectin led to an increase of the number of EPCs. Adiponectin induced EPC differentiation into network structures and served as a chemoattractant in EPC migration assays. These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity-related cardiovascular disorders.
摘要
肥胖相关疾病与内皮祖细胞（EPC）功能受抑制有关。脂联素是一种源自脂肪组织的蛋白质，在肥胖和糖尿病患者体内表达下调。在此，我们研究了脂联素对内皮祖细胞的影响。在脂联素缺乏（APN-KO）的小鼠中，后肢缺血并未使内皮祖细胞水平升高。腺病毒介导的脂联素递送使野生型和APN-KO小鼠的内皮祖细胞水平均有所升高。用脂联素孵育人外周血单个核细胞会导致内皮祖细胞数量增加。脂联素诱导内皮祖细胞分化为网络结构，并在内皮祖细胞迁移试验中作为趋化因子。这些数据表明，低脂联素血症可能导致肥胖相关心血管疾病患者中观察到的内皮祖细胞水平降低。
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