Dezortova Monika, Hajek Milan
MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.
Eur J Radiol. 2008 Aug;67(2):240-249. doi: 10.1016/j.ejrad.2008.02.035. Epub 2008 Apr 21.
Spectral appearance and concentrations of the most prominent metabolites are affected by brain development. This knowledge is essential for the detection of pathological changes in pediatric patients. This paper discusses specific conditions of MR spectroscopic examination of children and the effects of age on MR spectra quality and quantitation of the studied metabolites. Clinical examples show several diseases that are reflected in changes in (1)H MR spectra due to pathological alterations in the biochemical pathways of the observed metabolites. Attention is given to the main metabolites such as N-acetylaspartate, creatine/phosphocreatine, cholines, lactate, inositol, etc.
最显著代谢物的光谱特征和浓度受大脑发育的影响。这一知识对于检测儿科患者的病理变化至关重要。本文讨论了儿童磁共振波谱检查的具体情况以及年龄对磁共振波谱质量和所研究代谢物定量的影响。临床实例展示了几种疾病，这些疾病由于所观察代谢物生化途径的病理改变而反映在氢磁共振波谱的变化中。重点关注了主要代谢物，如N - 乙酰天门冬氨酸、肌酸/磷酸肌酸、胆碱、乳酸、肌醇等。
