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对于非计划性透析患者,快速启动腹膜透析是否可行?一项单中心经验。

Is rapid initiation of peritoneal dialysis feasible in unplanned dialysis patients? A single-centre experience.

作者信息

Lobbedez Thierry, Lecouf Angelique, Ficheux Maxence, Henri Patrick, Hurault de Ligny Bruno, Ryckelynck Jean-Philippe

机构信息

Nephrology Department, CHU Clemenceau, Avenue G Clemenceau, 14033 Caen Cedex, France.

出版信息

Nephrol Dial Transplant. 2008 Oct;23(10):3290-4. doi: 10.1093/ndt/gfn213. Epub 2008 Apr 19.

Abstract

BACKGROUND

Starting dialysis in an unplanned manner is a frequent situation in a dialysis centre even for patients with a regular nephrology follow-up. For no clear reason, chronic haemodialysis (HD) is more frequently used than peritoneal dialysis for unplanned dialysis patients.

OBJECTIVE

The purpose of this study was to evaluate the results of a dialysis policy dedicated to unplanned dialysis patients. The aim of this policy was to increase the use of peritoneal dialysis (PD) in an attempt to reduce the need for tunnelled catheter.

METHODS

One hundred seventy-one patients from a single centre, who started dialysis between 1 January 2004 and 31 December 2006, were prospectively followed until 31 December 2006. Unplanned dialysis patients were defined as patients entering in dialysis with no vascular access or peritoneal dialysis catheter. PD was presented as a modality of choice for renal replacement therapy to avoid the need for a tunnelled HD catheter.

RESULTS

There were 60 unplanned dialysis patients during the study period. Among these patients, 34 agreed to be treated by PD. Compared with unplanned peritoneal dialysis patients, unplanned haemodialysis patients had a greater modified Charlson's comorbidity index (5.9 +/- 2.4 versus 4.4 +/- 1.9, P < 0.05). The mean duration of the temporary catheter period was 32 +/- 29 days (median: 24 days) for haemodialysis patients compared with 26 +/- 21 days (median: 25 days) for peritoneal dialysis patients (P = NS). The initial hospitalization duration was similar in haemodialysis patients and peritoneal dialysis patients (24 +/- 28 versus 30 +/- 33 days; median value: 17 versus 20 days, P = NS). PD was started 8.6 +/- 10 days (median: 4 days) after catheter insertion. A tunnelled catheter was used only in three patients until peritoneal dialysis was initiated. Acute automated peritoneal dialysis was used in 19 patients. Among 26 haemodialysis patients, 23 were dialyzed through a tunnelled catheter. Of these 23 patients, 15 were successfully converted to fistula. Median time for fistula creation was 2.6 months after dialysis initiation; median time for fistula utilization was 4.4 months. Actuarial patients survival at 1 year was 79% on haemodialysis compared with 83% on peritoneal dialysis (P = NS). After adjustment of the initial modified Charlson's comorbidity index, dialysis modality had no impact on patient's survival. There was no significant difference between haemodialysis patients and peritoneal dialysis patients regarding survival free of re-hospitalization. Actuarial survival free of peritonitis was 73% at 6 months and 58% at 1 year.

CONCLUSION

Peritoneal dialysis is a safe and efficient alternative to haemodialysis for unplanned dialysis patients. Peritoneal dialysis offers the advantage of reducing the need for tunnelled catheter in unplanned dialysis patients.

摘要

背景

即使是接受定期肾脏科随访的患者,在透析中心非计划性开始透析的情况也很常见。原因不明的是,对于非计划性透析患者,慢性血液透析(HD)比腹膜透析更常被使用。

目的

本研究的目的是评估一项针对非计划性透析患者的透析策略的结果。该策略的目的是增加腹膜透析(PD)的使用,以减少隧道式导管的需求。

方法

对2004年1月1日至2006年12月31日期间在单一中心开始透析的171例患者进行前瞻性随访,直至2006年12月31日。非计划性透析患者定义为开始透析时没有血管通路或腹膜透析导管的患者。PD被作为肾脏替代治疗的一种选择方式提出,以避免使用隧道式HD导管的需求。

结果

研究期间有60例非计划性透析患者。在这些患者中,34例同意接受PD治疗。与非计划性腹膜透析患者相比,非计划性血液透析患者的改良Charlson合并症指数更高(5.9±2.4对4.4±1.9,P<0.05)。血液透析患者临时导管使用期的平均时长为32±29天(中位数:24天),而腹膜透析患者为26±21天(中位数:25天)(P=无显著性差异)。血液透析患者和腹膜透析患者的初始住院时长相似(24±28对30±33天;中位数:17对20天,P=无显著性差异)。PD在导管插入后8.6±10天(中位数:4天)开始。在开始腹膜透析之前,仅3例患者使用了隧道式导管。19例患者使用了急性自动化腹膜透析。在26例血液透析患者中,23例通过隧道式导管进行透析。在这23例患者中,15例成功转为内瘘。内瘘建立的中位时间为透析开始后2.6个月;内瘘使用的中位时间为4.4个月。血液透析患者1年的精算生存率为79%,而腹膜透析患者为83%(P=无显著性差异)。在调整初始改良Charlson合并症指数后,透析方式对患者生存率没有影响。血液透析患者和腹膜透析患者在无再次住院生存方面没有显著差异。无腹膜炎的精算生存率在6个月时为73%,1年时为58%。

结论

对于非计划性透析患者,腹膜透析是血液透析的一种安全有效的替代方法。腹膜透析的优势在于可减少非计划性透析患者对隧道式导管的需求。

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