儿茶酚-O-甲基转移酶（COMT）基因Val158Met多态性与抗精神病药物所致迟发性运动障碍风险之间的关联。
The association between COMT Val158Met gene polymorphism and antipsychotic-induced tardive dyskinesia risk.
作者信息
Lv Zhiyu, Rong Benbing, Tong Xiang, Li Xiaohong, Chen Xiu, Wang Xixi, Li Zuoxiao
机构信息
a 1 Neurology Department , The Affiliated Hospital of Luzhou Medical College , Luzhou , China.
b 2 Neurology Department, West China Hospital/West China School of Medicine , Sichuan University , Chengdu , China.
出版信息
Int J Neurosci. 2016 Nov;126(11):1044-50. doi: 10.3109/00207454.2015.1089504. Epub 2015 Sep 23.
PURPOSE
Catechol-O-methyltransferase (COMT) Val158Met gene polymorphism has been implicated the association with Tardive dyskinesia (TD) risk. However, lots of studies have reported contradictory results, so we conducted a meta-analysis to investigate the association between the COMT Val158Met gene polymorphism and TD susceptibility.
MATERIALS AND METHODS
The PubMed, Embase, China National Knowledge Internet and Wanfang Database were researched up to 5 January 2015. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the relationship, and the statistical analyses were carried out by STATA 11.0 software.
RESULTS
In total, 1206 cases and 1680 controls from 11 case-control studies were included in the present study. The overall and subgroup pooled results indicated no significant association between COMT Val158Met gene polymorphism and TD susceptibility in all gene models (AA + AG vs.
GG, OR: 0.98, 95% CI = 0.76-1.26, P = 0.87; AA vs. AG +
GG, OR: 1.15, 95% CI = 0.93-1.42, P = 0.271; AA vs.
GG, OR: 1.15, 95% CI = 0.90-1.49, P = 0.27; AG vs.
GG, OR: 0.95, 95% CI = 0.80-1.14, P = 0.59; A vs.
G, OR: 1.05, 95% CI = 0.93-1.17, P = 0.43).
CONCLUSION
The study suggested COMT Val158Met gene polymorphism may not be an independent risk factor for TD susceptibility, especially in East Asians.
目的
儿茶酚-O-甲基转移酶（COMT）Val158Met基因多态性与迟发性运动障碍（TD）风险的关联一直备受关注。然而，许多研究报告了相互矛盾的结果，因此我们进行了一项荟萃分析，以研究COMT Val158Met基因多态性与TD易感性之间的关联。
材料与方法
检索截至2015年1月5日的PubMed、Embase、中国知网和万方数据库。采用比值比（OR）和95%置信区间（95%CI）评估两者关系，并使用STATA 11.0软件进行统计分析。
结果
本研究共纳入11项病例对照研究中的1206例病例和1680例对照。总体和亚组汇总结果表明，在所有基因模型中，COMT Val158Met基因多态性与TD易感性之间无显著关联（AA + AG vs. GG，OR：0.98，95%CI = 0.76 - 1.26，P = 0.87；AA vs. AG + GG，OR：1.15，95%CI = 0.93 - 1.42，P = 0.271；AA vs. GG，OR：1.15，95%CI = 0.90 - 1.49，P = 0.27；AG vs. GG，OR：0.95，95%CI = 0.80 - 1.14，P = 0.59；A vs. G，OR：1.05，95%CI = 0.93 - 1.17，P = 0.43）。
结论
该研究表明COMT Val158Met基因多态性可能不是TD易感性的独立危险因素，尤其是在东亚人群中。
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