Almeida Patrícia Lopes de, Gandolfi Lenora, Modelli Inês Cristina, Martins Rita de Cássia, Almeida Rodrigo Coutinho de, Pratesi Riccardo
Graduate Program in Health Sciences, University of Brasília School of Health Sciences, Brazil.
Arq Gastroenterol. 2008 Jan-Mar;45(1):69-72. doi: 10.1590/s0004-28032008000100013.
Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients.
To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients.
First degree relatives of celiac patients attending the Brasilia University Hospital Pediatric Gastroenterology Outpatient Clinic or the Celiac Disease Investigation Center, Brasília, DF, Brazil, between March 2001 and November 2004 were invited to undergo serological screening for celiac disease applying the IgA anti-endomysium antibody test (IgA-EMA). All positive IgA-EMA sera underwent a second screening using the IgA anti-tissue transglutaminase antibodies test. Duodenal or small intestinal biopsies were performed in all subjects positive to serological testing. Biopsy samples were classified as type (O) normal, (I) infiltrative, (II) infiltrative hyperplastic, (III) flat destructive, and (IV) atrophic hypoplastic. The final diagnosis was ascertained in subjects showing positive serological tests and a grade I to III small intestinal lesion.
Nine new cases of celiac disease were found among the 188 first degree relatives tested (4.8%).
The present study confirms the high prevalence of celiac disease among first degree celiac patients relatives and reinforces the need of extensive diagnostic screening in this specific group.
多项研究表明，乳糜泻是一种发生在遗传易感性个体中的自身免疫性疾病，在乳糜泻患者的亲属中高度流行。
确定一组巴西乳糜泻患者一级亲属中乳糜泻的患病率。
邀请2001年3月至2004年11月期间在巴西利亚大学医院儿科胃肠病门诊或巴西利亚联邦区乳糜泻疾病调查中心就诊的乳糜泻患者的一级亲属接受使用抗肌内膜抗体检测（IgA-EMA）进行的乳糜泻血清学筛查。所有IgA-EMA血清阳性者均使用抗组织转谷氨酰胺酶抗体检测进行二次筛查。对所有血清学检测呈阳性的受试者进行十二指肠或小肠活检。活检样本分为（O）型正常、（I）型浸润性、（II）型浸润增生性、（III）型扁平破坏性和（IV）型萎缩发育不全性。在血清学检测呈阳性且小肠病变为I至III级的受试者中确定最终诊断。
在接受检测的188名一级亲属中发现了9例新的乳糜泻病例（4.8%）。
本研究证实了乳糜泻患者一级亲属中乳糜泻的高患病率，并强调了对这一特定群体进行广泛诊断筛查的必要性。
