Singh Prashant, Arora Shubhangi, Lal Suman, Strand Tor A, Makharia Govind K
Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Am J Gastroenterol. 2015 Nov;110(11):1539-48. doi: 10.1038/ajg.2015.296. Epub 2015 Sep 29.
First-degree relatives (FDRs) of patients with celiac disease (CD) are at high risk for CD and prevalence among them varies from 1.6 to 38%. The risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, or daughter of index patient with CD is not known. We conducted a meta-analysis and calculated pooled prevalence of CD among FDRs, second-degree relatives (SDRs), and specific relations with index patient.
On search of literature, 2,259 articles appeared of which 54 articles were included in this meta-analysis. Diagnosis of CD was based on standard criteria.
Pooled prevalence of CD was 7.5% (95% confidence interval (CI) 6.3%, 8.8%) in 10,252 FDRs and 2.3% (95% CI 1.3%, 3.8%) in 642 SDRs. Pooled prevalence of CD was highest in siblings (8.9%), followed by offsprings (7.9%) and parents (3.0%). Female FDRs had higher prevalence than male FDRs (8.4% vs. 5.2%, P=0.047). While sisters and daughters of index patient had the highest risk of having CD (1 in 7 and 1 in 8, respectively), the risk was 1 in 13 in sons, 1 in 16 in brothers, 1 in 32 in mothers, and 1 in 33 in fathers. There were also differences in the pooled prevalence of CD in FDRs according to their geographic location.
Pooled prevalence of CD among FDRs is 7.5% and varies considerably with their relationship with the index patient. The risk of CD in FDRs also varies according to gender and geographical location.
乳糜泻（CD）患者的一级亲属（FDRs）患CD的风险很高，患病率在1.6%至38%之间。如果FDR是CD指数患者的姐妹、兄弟、母亲、父亲、儿子或女儿，其患CD的风险尚不清楚。我们进行了一项荟萃分析，并计算了FDRs、二级亲属（SDRs）以及与指数患者的特定关系中CD的合并患病率。
在检索文献时，共出现2259篇文章，其中54篇文章纳入了本荟萃分析。CD的诊断基于标准标准。
10252名FDRs中CD的合并患病率为7.5%（95%置信区间（CI）6.3%，8.8%），642名SDRs中为2.3%（95%CI 1.3%，3.8%）。CD的合并患病率在兄弟姐妹中最高（8.9%），其次是后代（7.9%）和父母（3.0%）。女性FDRs的患病率高于男性FDRs（8.4%对5.2%，P = 0.047）。虽然指数患者的姐妹和女儿患CD的风险最高（分别为七分之一和八分之一），但儿子的风险为十三分之一，兄弟为十六分之一，母亲为三十二分之一，父亲为三十三分之一。根据地理位置，FDRs中CD的合并患病率也存在差异。
FDRs中CD的合并患病率为7.5%，且随其与指数患者的关系而有很大差异。FDRs中CD的风险也因性别和地理位置而异。
