Rapaport D, Colletto G M, Vainzof M, Duaik M C, Zatz M
Departamento de Biologia, Universidade de São Paulo, Brazil.
Growth Regul. 1991 Mar;1(1):11-5.
Growth rate was assessed in 187 boys affected with Duchenne muscular dystrophy (DMD) and bone age in 127 among them. Patients' heights were compared with their normal sibs, with expected stature according to midparents' stature and with normal Brazilian children of comparable age. The results showed that DMD boys have a normal length and weight at birth, but a delayed growth starting during the first years of life with a mean approximate decrease of -6.00 cm according to the expected height of the normal Brazilian population. The proportion of DMD patients with short stature (below the 3rd centile) was similar in younger boys (up to 7 years) to that in the older group (more than 7 years) of affected boys. Bone maturation in DMD boys did not differ from their normal sibs. Weight was also decreased in DMD patients as compared with normal sibs of comparable age.
对187名患有杜氏肌营养不良症(DMD)的男孩进行了生长速率评估,并对其中127名男孩进行了骨龄评估。将患者的身高与其正常同胞、根据父母身高预期的身高以及巴西同龄正常儿童进行了比较。结果显示,DMD男孩出生时身长和体重正常,但在生命的最初几年开始生长迟缓,根据巴西正常人群的预期身高,平均约下降6.00厘米。身材矮小(低于第3百分位数)的DMD患者在年幼男孩(7岁及以下)中的比例与年长组(7岁以上)受影响男孩中的比例相似。DMD男孩的骨骼成熟度与他们的正常同胞没有差异。与同龄正常同胞相比,DMD患者的体重也有所下降。